Klotho / FLGR242 (albumin-bound new tech)
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Mike Farber answers questions. A must-watch for avid researchers: https://streamyard.com/watch/eGeUWk6eREYS
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I took a blood test after two months of using alpha-klotho 10 mcg every 2 weeks. The results are concerning. My cystatin-c showed up at 1.04 while it was usually at 0.7-0.8 per many tests and never was as high. It corresponds to egfr of around 0.7 while it used to be over 1.0. I can't pinpoint it to klotho with 100% confidence, but it was the most relevant to kidney healh change since the last test.
I will take a pause of 3 weeks on it, and remeasure my cystatin-c, hopefully it's not a permanent kidney damage.
The other changes I made during this period were Tesa/ipa/cjc tries (mostly tesa) which raised my igf1, flgr242 at low dose, and testosterone introduction. I stop everything, retest, then introduce one by one if egfr is back on track.
Interestingly my creatinine level did not get higher bu it was high already. I attribute high creatinine to supplementing 10g creatine and working out, and relied on cystatin-c for my kidney health.
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A question I have not found a definitive answer to yet. Left a mixed 5mg flgr242 out overnite room temp. Wondered if it would still work. Basically found "will lose potency if left above 50F for over 8 hours, up to 50%". That's an average of what I found.
So - begs a question from me: if in my body and has a 1/2 life of lets just say 14 days, at 98.6F, why sooooo bad at room temp - 75F overnite?
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I’d like to load it in a pen, but I’m too chicken it’ll start to degrade so I take it pretty soon after recon’ing.
@MacLeeezy I mix mine 5mg w/ 1.5ml BAC. Then do MWF shots 30min before workout with weights. Do .5ml/shot so 5mg flgr242/week. Always keep in fridge, but just wondered about this temp thing. Only thing I bring to the table is alot of common sense (which seems to be UNcommon sense nowadays). A brainiack I'm certainly not, but love learning - and things just have to make sense to me. Only truths are numbers and physics, and as Elon says everything else is just a recommendation.
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A question I have not found a definitive answer to yet. Left a mixed 5mg flgr242 out overnite room temp. Wondered if it would still work. Basically found "will lose potency if left above 50F for over 8 hours, up to 50%". That's an average of what I found.
So - begs a question from me: if in my body and has a 1/2 life of lets just say 14 days, at 98.6F, why sooooo bad at room temp - 75F overnite?
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@mole They will, but what can you expect to hear? Nobody knows what happened in your particular case for your particular conditions. It can be guessed it lost a few percents of the complete proteins (those are long about 200 amino acid molecules). But I guess nothing bad will happen if you use it, maybe just a slightly less effectiveness, which will be unmeasurable in the long run.
Here is your answer in advance https://jaycampbell.com/blog/how-to-store-reconstituted-peptides/
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Response from BLL - IMO very informative. As I said before, I love learning and never settle for answers that are "should be" "probably ok" and the likes.
Here is the response:
Thank you for the thoughtful question, and we’re glad to hear you’ve been pleased with the product.
The two concepts are actually measuring different things. Stability in a vial refers to how well the reconstituted peptide maintains its chemical and physical integrity while being stored. Temperature, time, pH, light, oxidation, and other factors can contribute to degradation, which is why refrigeration is recommended after reconstitution.
A half-life in the body, on the other hand, describes how quickly a compound is cleared or metabolized after it enters a biological system. The environment inside the body is very different from a vial sitting at room temperature. Protein binding, including albumin binding, can affect distribution and can protect a compound from rapid clearance or degradation, thereby extending its circulating half-life.
So, a compound can require refrigerated storage after reconstitution while still having a comparatively long biological half-life at body temperature. The storage-stability timeframe and biological half-life are not directly interchangeable.
Because our products are sold strictly for research use only, we aren't able to provide guidance regarding human administration or individual use. However, I hope this helps clarify the distinction between storage stability and biological half-life. -
I’m sure those of you on the BLL mailing lists have seen the announcements that they are significantly lowering prices for klotho and FLGR242 going forward. For everyone else, regular pricing of $299/2 vials. Much more ‘affordable’ now.
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I’m sure those of you on the BLL mailing lists have seen the announcements that they are significantly lowering prices for klotho and FLGR242 going forward. For everyone else, regular pricing of $299/2 vials. Much more ‘affordable’ now.
I’m sure those of you on the BLL mailing lists have seen the announcements that they are significantly lowering prices for klotho and FLGR242 going forward. For everyone else, regular pricing of $299/2 vials. Much more ‘affordable’ now.
I did not get the email. Thanks for the update though.
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Well, it’s not a secret, so here you go.
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4 week update- I’ve been noticeably stronger in the gym lately and have actually set a few PR’s. Still way more vascular than normal. I’d been averaging 8-10lbs weight loss a month. Since starting FLGR it has slowed to maybe 1-2lbs but my smart scale shows fat decreasing and muscle increasing. Disclaimer: I started enclomaphine around the same time so there’s really no telling which one is doing the heavy lifting but my test went from 677 to 900 on 6.25mg of Enclo daily. Taking 2 vials of slim assist every Sunday. It’s either working, the increased testosterone is working, or is
a top tier placebo. Either way I’m happy thus far -
4 week update- I’ve been noticeably stronger in the gym lately and have actually set a few PR’s. Still way more vascular than normal. I’d been averaging 8-10lbs weight loss a month. Since starting FLGR it has slowed to maybe 1-2lbs but my smart scale shows fat decreasing and muscle increasing. Disclaimer: I started enclomaphine around the same time so there’s really no telling which one is doing the heavy lifting but my test went from 677 to 900 on 6.25mg of Enclo daily. Taking 2 vials of slim assist every Sunday. It’s either working, the increased testosterone is working, or is
a top tier placebo. Either way I’m happy thus far4 week update- I’ve been noticeably stronger in the gym lately and have actually set a few PR’s. Still way more vascular than normal. I’d been averaging 8-10lbs weight loss a month. Since starting FLGR it has slowed to maybe 1-2lbs but my smart scale shows fat decreasing and muscle increasing. Disclaimer: I started enclomaphine around the same time so there’s really no telling which one is doing the heavy lifting but my test went from 677 to 900 on 6.25mg of Enclo daily. Taking 2 vials of slim assist every Sunday. It’s either working, the increased testosterone is working, or is the a top tier placebo. Either way I’m happy thus far
I am also taking enclomiphine but 12.5mg 3x a week and 1 vial of slim assist (2mg FLGR) weekly. It's been 6 weeks for me. Did you titrate up to 2 vials of slim assist or did you just start off at 2 vials? I'm thinking of moving up on it but wondering if I should do 2 vials at once or split it between the week. Interested in hearing your protocol as we seem to be on the same thing.
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Yesterday, JC hosted Mike Farber again who basically answered questions about Alpha-Klotho, FLGR-242, and BioLean, which will soon be available. He also mentioned the drop in price for the signature peptides. I do have the Jamie AI Executive Summary of the talk.
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