5-Amino-1MQ Research
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I thought about running 5-Amino-1MQ together with NAD+, but when I looked into it, I found some information that this might actually be counterproductive? What do you guys think?
@jamesboyles 5-Amino-1MQ increases cellular NAD+ levels by blocking an enzyme called NNMT, which normally breaks down the building blocks needed to make NAD+. If you still want to add NAD+ I would personally do low dosages just in case. I would rather run 5amino' with MOTS. The trick here is to run the mitochondria on mostly fatty acids instead of glucose. Scroll up and see what else it does w fats.
"How It Works with NAD.
- Blocks NNMT: It stops nicotinamide N-methyltransferase (NNMT), an enzyme that tags NAD+ building blocks for disposal.
- Saves Precursors: By stopping that enzyme, it keeps nicotinamide available to build more NAD+.
- Raises Energy: Preclinical studies show this boosts cellular NAD+ levels by roughly 1.2 to 1.6-fold, helping cells create energy more efficiently."
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Update- I moved to 25mg subq as @randy did, noticed no difference. However some weeks ago I added oral 5-Amino PM on top of my AM subq. Can't find factual research in regards to subq being bioavailable/efficacious (some say it is not), therefore hedging my bets. Frustrating. If someone finds reliable info (not a YT influencer...lol) please post and reference? TIA! At the moment, I plan to be on it indefinitely due to the NAD+ recycling benefits, love my NAD.
@PeptidePete I though this Alex Kikel Seminar was decent
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@PeptidePete I though this Alex Kikel Seminar was decent
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@EXTROPIAN If you like that one he has a good Mitochondrial Peptide Seminar (all the good ones) in his video library on his YouTube page too. Most his seminar videos are great lessons.
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This HVY is very potent compared to other 5 am I’ve researched. I had to back down to 5, but also got little bubbles at IS , they eventually go away, but it’s kind of strange. Don’t experience this with other 5 AM such as nexaph.
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@WisGal64 Back down to 5? 5mgs I assume? What did you start with that was too much? I have mine but haven't used it yet. I am thinking after my labor day vacation.
@WisGal64 Back down to 5? 5mgs I assume? What did you start with that was too much? I have mine but haven't used it yet. I am thinking after my labor day vacation.
Yes, 5mg, started at 15 where I normally am, but the jitters oof. Then backed down to 10, still too much, 5 seems ok, no jitters
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@WisGal64 Back down to 5? 5mgs I assume? What did you start with that was too much? I have mine but haven't used it yet. I am thinking after my labor day vacation.
Yes, 5mg, started at 15 where I normally am, but the jitters oof. Then backed down to 10, still too much, 5 seems ok, no jitters
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@WisGal64 @shaqdiesel FWIW, I found my happy place is 30mg. But I’m also a male, 6-2, 190lbs.
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I can't wait to try it. I do not have anything to compare it to though because this will be my first time researching on this product.
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I can't wait to try it. I do not have anything to compare it to though because this will be my first time researching on this product.
@Shaqdiesel This is my first experience as well. Hopefully you’ll like it.
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I prefer oral 5 amino 1q. But just ordered the 500mg bottles. Yes 500mg. 110 a kit. Im pretty stoked about it
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I take 50mg/.5ml of liquid 5amino daily. I don't feel any added energy, but I am testing nmn powder, mots, and nad+ also. I just hope it is fighting the fat.
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Taking 100 mg a day as pills for 4 weeks by now, I can't say I see of feel any difference I may associate with it. Giving it another month. I know that simply taking 500 mg Niacin bring my "intracellular NAD" over the high limit. So probably I don't have difficulties with NAD recycling and maybe NNMT blocker is not of much help for me. Technically it would be proper to do another "intracellular NAD" test to see if my baseline levels are increased, but I don't know if I want to spend $200 on it.
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My rat is 15 days into researching. He’s up to 20mg subq now. It’s hard to tell for sure what is placebo or if his weight loss plateau was about to break without 5 amino. But the plateau did break and he did notice a VERY mild increase in energy. It’s hard to describe the extra energy. It’s not like coffee or nicotine at all. It’s more like a 1% increase that sustains all day. When the end of the work day comes, he’s as alert and awake as he is normally at 9am. Again, it’s very subtle. Right now he’s only on Reta and just added the 5amino. Been on Reta and a calorie deficit for 3 1/2 months so the extra energy has really lifted his spirits and given him a second wind.
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Anyone else researching this one? Been doing a week of 25mg sub-q with good results, now moving to 50mg (full vial) per pin. The looks of it in the barrel are such that it will light the injection site on fire but it is a total nothingburger.
Seems the best to time the pin is 20 minutes or so subsequent to an NAD+ pin, which I am doing. 100mg-150mg NAD+ pin, then the 5-Amino 20 min later. Daily, no breaks. A nice double-rush of clean energy.
FWIW- I am 95% optimized with good muscle mass and low fat, 65 yrs old.
@PeptidePete with capsules I jumped up to 80mg and felt great, different bio availability and such, but cheaper and easy
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