5-Amino-1MQ Research

[Shaqdiesel]

@TBone subq in the stomach? How did the pin feel?

[WisGal64]

Thanks @tbone I will proceed with caution for sure, I like the 5 am boost but don’t need the jitters

[EXTROPIAN]

From what I personally understand about 5 amino-1mq is the following. Please feel free to add to further educate myself. :

1. 5-Amino-1MQ is designed to help the body use fat as energy by blocking an enzyme called NNMT, which reduces fat storage and increases cellular energy expenditure.

2. 5-Amino-1MQ forces your body to use fat as energy by activating cellular enzymes that control your metabolism, shifting fat cells from a "storage" mode to a "burn" mode

3. 5 amino 1mq kinda recycles NAD+. It acts as an enzyme blocker that stops your cells from wasting the building blocks needed to make NAD+.

Now using fat as the fuel, while NAD+ is the engine component that burns it. You cannot use NAD+ instead of fat for energy; your cells use NAD+ to extract energy from fat. The same way it does carbohydrates.
That's why you feel this *energy. Now keep in mind that fat contains more than twice the energy of carbohydrates per gram. Fat provides 9 calories per gram, whereas carbohydrates provide only 4 calories per gram.

After optimizing my mitochondria I now only run, well aways been running 1-2mg subQ every other day depending on my agenda. I have pushed it up to 4mg and felt a little to much so I titrate back down. Its not a serge/rush of energy but a significant amount of steady energy to get me through the day. I do not understand why these high dosages? Be patient this stuff is strong. Maybe my dosages are cause I have run it before with 500mcgs of Slurpy synergistically. But Slurpy has significantly given me endurance as for 5amino' more energy.

[TBone]

@Shaqdiesel Yes. Sub Q in the stomach. Absolutely NO issue whatsoever.

[Shaqdiesel]

@extropian Most people don't notice any effect until they get around 25mgs+ subq. The lower dosages are probably more of a placebo type effect. I believe Randy said he has gone up to about 50mgs but he didn't really notice any benefit after going past 25mgs, so he now does 25mgs.

[EXTROPIAN]

@Shaqdiesel Hmmm interesting.
I added 5amino-1mq and slu-pp-332 to my reta stack. While running my mitochondria stack (motsc, nad, ss-31) which made it even better running off fatty acids for fuel via 5amino and slupp . Must have been one hell of a placebo effect because since the first time I felt the difference. I went back on it yesterday. No mitochondria stack. Took 5amino-1mg and I felt it without Slurpy (need to recon anotherone). If I can run on placebo alone it would have save me quite a bit. Maybe you need to run it synergistically with others and not alone. Maybe you need to optimize your mitochondria and insulin sensitivity to make the best of it. Can't say it enough, foundation first.

[vpeps]

@EXTROPIAN I take 50mg 5-amino-1mq as a capsule 2 times a day. If I feel anything, it's a very mild flush sometimes. Not observed anything else yet, for 1 week.
I read/heard though that subq inj may be more bioavailable and that's why people take a lot less, like 1 mg.

[Shaqdiesel]

@EXTROPIAN @vpeptides In the end it is all N=1 research and we are all different. That is true on all peps and dosage. Some people take .5mg Reta and never have to go higher. Some shoot up to 8mgs before they actually start seeing any effect.

[jamesboyles]

I thought about running 5-Amino-1MQ together with NAD+, but when I looked into it, I found some information that this might actually be counterproductive? What do you guys think?

[EXTROPIAN]

@jamesboyles 5-Amino-1MQ increases cellular NAD+ levels by blocking an enzyme called NNMT, which normally breaks down the building blocks needed to make NAD+. If you still want to add NAD+ I would personally do low dosages just in case. I would rather run 5amino' with MOTS. The trick here is to run the mitochondria on mostly fatty acids instead of glucose. Scroll up and see what else it does w fats.

"How It Works with NAD.

1. Blocks NNMT: It stops nicotinamide N-methyltransferase (NNMT), an enzyme that tags NAD+ building blocks for disposal.
2. Saves Precursors: By stopping that enzyme, it keeps nicotinamide available to build more NAD+.
3. Raises Energy: Preclinical studies show this boosts cellular NAD+ levels by roughly 1.2 to 1.6-fold, helping cells create energy more efficiently."

[Mr Smurf]

5amino and Mots is a legendary combo for me

[EXTROPIAN]

@Mr-Smurf But it's a different kind of energy. Reminds me of the keto diet back in the days where you switch to ketosis for energy.

[bfuller]

@PeptidePete I though this Alex Kikel Seminar was decent

5-AMINO-1MQ SEMINAR & PROTOCOL

[EXTROPIAN]

@bfuller Good video. Thanks for sharing.

[bfuller]

@EXTROPIAN If you like that one he has a good Mitochondrial Peptide Seminar (all the good ones) in his video library on his YouTube page too. Most his seminar videos are great lessons.

[WisGal64]

This HVY is very potent compared to other 5 am I’ve researched. I had to back down to 5, but also got little bubbles at IS , they eventually go away, but it’s kind of strange. Don’t experience this with other 5 AM such as nexaph.

[Shaqdiesel]

@WisGal64 Back down to 5? 5mgs I assume? What did you start with that was too much? I have mine but haven't used it yet. I am thinking after my labor day vacation.

[WisGal64]

@Shaqdiesel said:

@WisGal64 Back down to 5? 5mgs I assume? What did you start with that was too much? I have mine but haven't used it yet. I am thinking after my labor day vacation.

Yes, 5mg, started at 15 where I normally am, but the jitters oof. Then backed down to 10, still too much, 5 seems ok, no jitters

[TBone]

@WisGal64 @shaqdiesel FWIW, I found my happy place is 30mg. But I’m also a male, 6-2, 190lbs.

[WisGal64]

@TBone said:

@WisGal64 @shaqdiesel FWIW, I found my happy place is 30mg. But I’m also a male, 6-2, 190lbs.

I’m wondering if it’s there is more or what is in this blend that I’m reacting so differently than other 5 am I’ve researched