As the owner of a FDA regulated and inspected 20-year old business selling direct-to-customer, the bottom line is as @randy described it (In multiple ways).

Set honest expectations and fucking meet them, if for some reason you cannot meet the expectations you set, then fix the fucking problem and communicate immediately. That's it, period, end of story.

Safety Note:

If you normally tend towards LOW blood pressure, Cagri will drop it even lower AND that can trigger a resting heart rate increase to compensate (tachycardia) severe enough to cause an ER visit. Effects exacerbated if using Reta which also can have a BP lowering effect. My poor wife went 144bpm and 89/62bp. Be careful with this one if the situation applies to you.

Obviously this "side-effect" is a benefit if you tend towards a HIGH blood pressure.

I've researched various GHK subq protocols up to 20mg daily, posted them here in the GHK thread. Currently 3mg am, 3mg pm, it has a very short half-life, ergo, multiple daily pins for those who are serious about seeing benefits.

3000+ genes upregulated, none downregulated. No evidence of tachyphylaxis, it works via gene expression modulation. Why would you ever want to "cycle" it? Based on my current understandings, I will "never" go off of it.

My labs, run every 4-6 weeks, are pristine. As always in this space, 99.9% of what you see and hear is utter baseless bullshit, you are well served to conduct your own deep dive.

Sunlight is the best disinfectant. Proverb, aphorism, reality.

Also, when it comes to setting customer expectations, there are no excuses. Period. I have decades of experience living that concept. I also ran a business while being in a different country every few weeks for 3 years. I never found myself making excuses to my customers. Laptops. VPN's. TeamViewer. Shipstation. XML integrations. OMS's. Tools of the trade, figure it out or GTFO.

Anyone else researching this one? Been doing a week of 25mg sub-q with good results, now moving to 50mg (full vial) per pin. The looks of it in the barrel are such that it will light the injection site on fire but it is a total nothingburger.

Seems the best to time the pin is 20 minutes or so subsequent to an NAD+ pin, which I am doing. 100mg-150mg NAD+ pin, then the 5-Amino 20 min later. Daily, no breaks. A nice double-rush of clean energy.

FWIW- I am 95% optimized with good muscle mass and low fat, 65 yrs old.

Just so that this fact (for me) is out there- inverse correlation of GHK-Cu dose and copper levels in plasma. So that trope is put to rest. Dose-up mofos...

119 ug/dL copper on 5-10mg GHK, 105 ug/dL on 15+mg.

105 on 15mg+ for weeks prior to test.

Inverse correlation.

You are welcome

As usual/always, you must do your own diligent research. PS- the entire testing results were stellar, better than ever. Not saying at all that is solely attributable to GHK, but to the full stack I am running. Above is one data point.

Forum blocks my "likes" after 20 per day <sad face> You all are funny..lol

Look, there is a case also to be made that signaling on a genetic level does not benefit from dosing more frequently than once every one or two days. Is a whisper sufficient? Or frequent shouts more effective? We just don't know because there are no human case studies.

With that said I observed no evidence that heroic doses cause any deleterious effects. N=1 for what that's worth, ya know? Did not notice blue tinting either, but that would be kind of cool. "No tats or piercings but I am blue"...haha!

65 year old hands today. Remember I live in Nevada with 10% typical humidity. Thank FLGR242 for the increased vascularity (different thread).

As previously mentioned, based on no hard evidence whatsoever, it is my opinion GHK subq may be a very beneficial agent for us older folks. Only time will tell.

Also, go do a search for the speed at which skin cells turnover, that is one very compelling reason I do not cycle. Make sense?

Cheers-

@WisGal64 said in GHK Cycle:

Alright, @peptidepete you have shown me some very weak gaps in my research, learning in progress I was up before the butt crack of dawn, and went down the rabbit hole. You are 100% accurate, what I found was eye opening to say the least. Thank you for sharing your insight and knowledge!

That is so awesome! Very glad to read this.

The reason I don't "spoon feed" answers is exactly this! The personal discovery of "oh holy shit I did not know that! SO COOL" is priceless. Never trust anyone with an affiliate code or telling you "facts" because 99.9% of yappers know JS.

I have zero to sell, don't "coach", have no YouTube, nothing. I just love to to discover that with helps me fight the "system" that is otherwise designed for one thing- to keep me weak and sick.

Onward upward!

I've personally researched both capsules and liquid from 50mg to 500mg daily. MILLI-gram.

Various daily timings (split/not split). The liquid hits like a sledgehammer as I posted here in a different thread. It is a very interesting material, I personally have zero interest in doses less than 100mg, and find 200mg-400mg to be very interesting. I stacked it with ATX-304 and found that nice. Stacked with BAM-15, it's too much for this researcher...whew...lol

My gut feeling is it's best to cycle on/off the SLU, I was on for approx 6 weeks, I'm going to take 6 weeks off. Coming from a researcher who does generally NOT believe in "cycling". Shit's potent, I'm going to respect this one.

Careful shoppers can find strong-value cost per mg suppliers with a modicum of effort. Cheers-

Pick your battles otherwise you'll be fighting constantly with everything. So many bigger fish to fry. Are you eating sugar? Seed Oils? Carbs? Food with anti-nutrients? Heavy metal testing of peptides is number one million on the list of things I care about. (I pay for a shtload of frequent blood and health testing so I DO care about things that matter)

You want something to care about? Do some research in regards to toxins in shrimp, crabs, lobsters and God forbid fish liver. Let me know when you absolutely avoid all of those and we can have a conversation.

You are welcome

Thought of some strings I'd highly recommend curious folks to pull on:

1. The gene therapies for all their promise seem to have not worked well. Poor results. Both minicircle and plasmid.
2. As always happens grifters are identified- Adeel Khan (no surprise).
3. The inventor of FLGR242 and a-Klotho MAB, Mike Farber, is worthy of a deep dive, I like everything I see and hear.
4. My wife (petite) has been on FLGR for 4 months now at 2mg once per week and she has gone from having ZERO desire for variable resistance workouts to being a little workout monster and looks great.
5. The monoclonal antibodies aside from being simply unattainable have in most cases quite serious unwanted side effects.

I thank my lucky stars I immediately recognized the value on offer when the two MAB (Modified Albumin Binding) agents were introduced by BLL last year, Mike Farber is in the same situation I am, aging and wanting some good, REAL, solutions. He eats his own cooking. I'm so thankful he is who he is. That's all for me for a while because I sound like a paid shill, but I am a PAYING shill...lol. Dig deep my friends, trust no one. And never ever forget when you are reading or watching something, "THEY" want you weak and compliant, I'm shocked FLGR/a-Klotho can still be bought. Do your homework, be the absolute best you can be.

Heavy-metals in peptides is and has been a non-issue. Zero concern in my world. NONE. To my knowledge in the history of the world they have never been found in remotely significant amounts. May as well test for fent while you are at it. Cheers

I gotta say, this thread has restored my faith in at least a subset of humanity. Thank you. I love you all.

LOL

Now how can we all find each other when the time comes? lol

said in Sterlization grade filtering?:

Worthy of a look and priced attractively: Cobetter 0.2μm Hydrophilic PVDF Syringe Filters for Sterile Filtration

Those who care can investigate PES vs PVDF (both great) for water based agents.

Gratuitous supplies pics...lol

Awesome video! A ballsy scam deserves a ballsy exposure. Check, and CHECK lol

@ResearchCat said in MOTS-c Subcutaneous Research Dosing Protocol:

Have you had any problems with going IM on back of arm? I had to stop when I lost weight because my Tirz was hitting muscle and I was bruising since I can’t pinch and shoot. Or are you using a short needle so no problem? Thx.

(For Tirz, subjectively, back of arm is my preferred location. Now doing muffin top. Still effective, but I need all the real estate I can get. )

Short needle 5/16", never an issue (so far) keeping it sub-q and no accidental IM. Least ISR's, easiest skin to penetrate.

@Radasaurus said:

@Randy
Go to trustpilot.com. Here’s also a link to Finnrick’s testing results for Nexaph, which is also very negative: https://www.finnrick.com/vendors/nexaph

A-ha...Someone either needs higher quality due diligence or "something else" is afoot.

Finnrick has zero credibility in my world and I care deeply about quantified quality. This particular red herring has been debunked multiple times but I guess the hook continues to catch unsuspecting fish (holy mixed metaphors). IYKYK.

Much of my deep stash is NEXAPH and I love doing business with them.

Cheers

Folks understandably ask "why" the heroic dosing. To see what is on the other side is the answer Strikes me as a reasonable experiment. Primary curiosity- assist in keeping my post-GLP3 skin tight. I am only looking to lose my ~20lbs of visceral fat but still getting some "drapy" skin nevertheless. Also, will it affect my male pattern baldness. I experienced no negative sides on daily 7.5-10mg GHK-Cu.

Pain, yes, it can vary between nothing, and 24-36 hours not sleeping on that side pain...lol. For me the upper-outer quadrant of the buttock is where the magic is. Belly/Midriff area inevitably gets me a lump, sometimes for weeks.

Will update thread as time passes- cheers

@MacLeeezy said in SS-31 Dosage for Researching:

Any thoughts on the recent study: Gudiksen et al., Free Radical Biology and Medicine (2026) that talks about potentially running SS31 and Mots-c together instead of Ss31 first and then Motsc?

Just curious how your mice prefer to run both? Together or staggered?

I have only ever considered running both at the same time. Complimentary in every way. No such thing as "repair" then "grow" in my point of view, silly concept.

My stack: SS-31/NAD+/MOTS/5-AMINO to start, titrated up in frequency/dose, then when I completed and discontinued the SS-31 50mg per day for 60 days, added O-304/SLU/BAM-15 to the others. LOVE IT. Keep in mind, I am very well optimized in general, so working on the top of the pyramid. Not the stack for everybody depending upon individual sensitivities.

Freebie- if you are serious about optimizing mitochondria, you darn well better be incorporating the very best EPA/DHA/DPA sources, specifically fish eggs, preferably sturgeon (suggest the reader research it as I did). The fatty acids are taken up into the all your cell membranes over time. It's freaking crazy stuff, search it and learn it. No one ever talks about this...except me. A "superpower" addition to a serious and effective mitochondrial stack. You're welcome

@PeptideEd said in SS-31 Dosage for Researching:

@peptideed do you have a preferred source of sturgeon eggs?

Yeah...you have to let your wallet be your guide on this one In nutritional ranked order (seriously, big differences):

Sturgeon- I look for 1kg tins which is where best value per gm/oz is found and last me 1.5-2 weeks per tin in spite of the suggestion they be used in days. I keep the tin(s) in a vacuum bag except when serving. Look for discounts which is what I do. I personally like Bester, but others are good and can be found on Amazon.

Paddlefish is an alternative but releases oil in the tin and flavor/texture not as nice, price is approx -50% vs sturgeon.

Salmon roe is even lower cost per gm/oz but definitely an acquired taste, buy the wild ones shipped frozen!

Trout/flying fish roe is wholly inferior nutritional quality, I would not use.

Repair...Optimize (roe)...Uncouple. My big picture protocol.

This approach I'm sure sounds batshit crazy to some, but serious researchers will understand.