Peptide Critic Community

@spaceghost Wow! Huge changes! Congrats on the hard work! Hepatic fat, NAFLD, is so bad as you already know. Look at Tesa/Ipa, or, better yet the nectar itself. So many good sources. As you alluded to, Reta (if tolerated) would be especially good for eliminating liver fat.

Presumably you consume ZERO sugars and ZERO fruit juices as that converts directly to liver fat. Fruit juice is SO bad for people, it is poison.

Seems to me FLGR would be magic for you. Please be sure to confirm or deny if you try it! As previously emphasized, give a min of 3 months to evaluate effects.

Wow I leave for a few days and the thread goes nuts

Live stream last night with Jay C and Mike Farber brought out an interesting tidbit- using eGFR and (while not specifically mentioned I think Cystatin C reading in addition) to help dial in your Klotho dosing regimen. Farber says do NOT change the dosing, instead, adjust the days. For example "typical" admin would be one vial every 14 days. However if you have kidney issues, dial back a day or two then measure eGFR to see if any change (improvement). Reduce to a minimum (no less days between dosings than) every 8 days for the administration (as indicated by eGFR improvement or lack therof).

Some folks have baseline kidney issues, others of us may be researching agents that can affect, be "hard", on the kidneys. Klotho seems to be a very otherwise healthful tool to dial-in kidney support. It makes sense.

Farber was emphatic to say don't adjust Klotho DOSE, instead, adjust the administration TIMINGS. If anyone knows, he knows, he invented the product and has only one kidney.

Side note on FLGR- as previously mentioned I moved to research more aggressively and dose FLGR 15mg per week using a schedule of Tues/Thurs/Sat. I've noticed no negatives and while subjective, feel and look leaner.

I'd imagine individual variability here would be prevalent. If you are genetically gifted with naturally higher myostatin inhibition, you may not see as much or any improvement with higher dosing. All speculation. I'm staying on 15mg per week for a period of time for research purposes.

Farber also mentioned out of thousands of FLGR users, not one adverse reaction report.

Side note 2: I would not touch "stem calls" in any form or fashion with a ten-foot pole for a multitude of reasons. "KNOWLEDGE is knowing HOW to do something, WISDOM is knowing NOT too".

Side note 3: @spaceghost You would be a fascinating "case study". Variable-resistance training/sprinting, eating right (no excuses) is a MUST DO in combo with FLGR. There are multiple posters in-thread who have and will attest to that fact. Fucking go for it my man!

#4 @evelyn WOW! Awesome! My petite wife 40yr old remains on 2.5mg per week and looks awesome! She is NOT getting vascularized which I find interesting because I'm veiny AS HELL lol. She just looks "taut".

It's a joy to see the high-quality thread remains so

@vpeptides said:

@PeptidePete I did watch the video, thank you, I really liked it. That's why I asked. She didn't directly reference FOXO4-DRI, only said it is only her hypothesis, not a theory, no proof, that it's not a great idea to use senolytics because in the bone marrow you are going to wash out the senescent precursor cells to the stem cells, and it is better to have at least senescent cells there than just empty holes.
There is also a bone marrow peptide extract Bonomarlot (Bonocore) that is claimed to restore red bone marrow to supply stem cells, I am planning to research it too.

The point is that once you lose/kill/remove the few stem cells you have remaining, THAT'S IT. They NEVER grow back or can be replaced. That is the current understanding. I'm 65, I only have a few left unless I already burned them with my FOX04 course.

Humanin...I researched this heavily before dosing, I was very interested, and chose NOT to use it even once. I'd urge you to look very carefully before using it.

Spoiler- research the different versions of humanin, I would not touch it.

No humanin, sure as hell no FOX04. Far too many unknowns, said as a peptide fan who ran GHK-Cu at 15-20mg per day for months.

@WowwyZowwy said:

@stevencarter
Josh Holyfield's take...
https://youtube.com/shorts/W7_ajSR8-S8?si=b4nv03GgjMgZTEW1

Dude...

This clown (Holyfield) has no clue what he is talking about, as already noted multiple times downthread.

If you don't understand my comment, then you are not understanding Follistatin (details downthread). AI generated slop does not equal wisdom.

@diegoc said:

Whats done is done… move on

Absolutely

@vpeptides said:

@PeptidePete said:

I now deeply regret having done an injection of FOX04-DRI.

Do you think now it kills off too much of the senescent cells? You need to leave some for its purposes or simply to carry-on the genome?

Watched the Liz Parrish video I linked. Also her others

Thanks for sharing the journey my friend!

Bristol #4 is the desired outcome (Look it up if you don't understand)

Oysters With Vit C FTW!! You understand the intricacies brother. C or citrus juice, either is good. The C gave me very bad heartburn, the citrus not. Individual variability.

Low hydration-high hematocrit...well I'll be darned?? (wink wink)

I gotta say, this thread has restored my faith in at least a subset of humanity. Thank you. I love you all.

LOL

Now how can we all find each other when the time comes? lol

Same as HazmatGuy I like it dosed upon waking, then again late afternoon. Total of the split dosing 300mg-400mg per day. For reference I am 99% optimized and use it for the extra fat loss push and energy.

Oh yeah- regarding comments of "TOFI" Thin Outside Fat Inside issues.

As I previously posted I follow the regimen/protocol of Dr Sean Omara.

Beef/Seafood (Kai Gourmet=Fremantle Octopus)
Limited dairy including homemade yogurt (grass-fed A2 milk/half and half), raw aged/blue cheese in small amounts.
Fermented veg
Butter
Soy/Corn-free eggs
Fish roe
Organic Macadamia/Walnut butter in the yogurt (Blue Mountain Organics)
Organic farm sourced avocados (Corkysnuts.com)

No carbs, no fruit, no sugars of ANY kind, no flour, no veg.

Running/cycling is counter productive. Sprinting, short uphill fast walks, variable resistance training to failure approx 3x per week 20 min per session is my regimen.

Eating high protein while on FLGR is not an option. Jaquish Biomedical Fortagen is in my opinion the perfect protein in a sea of shit products.

Morning sun of course Dry sauna (not infrared)

Ok, buckle up, caffeinate, bookmark.

I said I was dropping to 2.5mg weekly FLGR. I lied. I changed my mind for the sake of personal research and due to new info coming in over the transom. For a period of time (x months) I am doing one vial FLGR 3x per week. So 15mg+/- per week. Xmas in July gave me 48 more vials to add to my existing stash of 46 vials.

I've previously mentioned Liz Parrish, linked below is her latest video. Readers of this thread are going to find it thought-provoking on multiple levels. Oh yeah...She invented Follistatin and Klotho gene therapy. I now deeply regret having done an injection of FOX04-DRI. Senescent cells are turning out to NOT be what they are sold as- dead waste. Does Follistatin have a max dose? Watch the video and get ready for shock.

Relevant side notes- it is my understanding the gene therapy (either of the two kinds) has not been as efficacious and durable as originally thought. BioLongevity Labs FLGR/Klotho FTW. Also- after watching the expose video on Adeel Khan I would NEVER do any injected gene therapy.

Shifting gears: Lesson learned the hard way- CHECK YOUR FERRITIN. Some "influencers" yapping YOU GOTTA GIVE BLOOD all the time. Wrong mofo, you need to get labs done and quantify where you are. Operating under information previously thought correct, I did therapeutic phlebotomies every two months for several years when I was incorrectly using injected testosterone. Terrible mistake, I tanked my ferritin to 15-20 ng/ml and the downstream effects of that are manifold. Including fcking up your thyroid function. NOT GOOD.

Doesn't matter WHAT your hematocrit is (specifically) that results from testosterone use, you should NEVER get bled. Pull that string...spoiler alert- tell me why blood doping athletes don't drop dead all the time. Fucking stupid ass mainstream "doctors" will fucking kill you with their ignorance.

So I am on a strict daily diet of baked (kills the pathogens) oysters + octopus legs + scrambled eggs for the next month or two to rebuild my levels. No, NOT beef (not as much heme iron!) and sure as fck not spinach (iron bound by nasty oxalates). Not liver because I don't want Vit A overdose (it's a thing). Do your research. Use lemon juice on the seafood to loosen the iron binding and enhance bioavailability. After a week, I already feel much better.

I think DIEGOC and I are brothers with different mothers. Anyone having a question for me, see if he has already spoke of it, because most likely I have the same view he does.

Another gear shift: A few weeks ago I initiated research of adding Test Cyp, EOD, to my OralOnly.com sublingual T in an effort to restart my Estradiol aromatization which I unintentionally took to zero due to an excess of an "oil" I've been researching. Lesson learned, that's research. I'll be tracking my labs to see if adding the EOD Cyp alters the otherwise perfect SHBG/Hematocrit/Hemoglobin/Prolactin/DHT on the sublingual only.

All this stuff is fully interconnected with FLGR/Klotho. It ALL works together as gears in a gearbox. One broken gear tooth or gear, and you'll be going nowhere fast.

Shift to overdrive- I have now researched Cell Factors MAX twice, I swear I feel a difference, feel "better" and "clearer". Yeah mushy stuff. Do your research, there is real science behind this. I just stocked up on sale. Never reconstitute with BAC water, ONLY Sterile Water!! BAC instantly degrades it.

Liz Parrish: https://youtu.be/Z4j5DL0-hM8?si=BMh_cejeEs9viGet

FLGR/Klotho info from Mike: https://streamyard.com/watch/diBBqZzAJkfC

@Stones67 said:

Josh doesn't know jack about this one. If he tries it for 4 months and then says it doesn't work it will confirm he's a buffoon. If he actually did a trial most likely he'd have to make another video with 'I was wrong' in the title. I sense this might be up your alley though!

That video tells me everything I need to know...about the person who created the video. Zero credibility. A buffoon.

On a side note, for research purposes, I am shifting to 2.5mg FLGR once per week starting tomorrow (2.5mg every Monday). Just completing a wash-out week to set up for the change. My wife will remain on 2.5mg per week, so we just split a vial per week.

If. IF, FLGR242 response curves parallel the Bimagrumab results, a good possibility but not yet known as fact, then half a year gives me the vast majority of the benefits, and I can taper back until we have a year of more of continued lack of negative signals. In other words, play cautious simply for the sake of doing so until BioLongevityLabs publishes results of currently ongoing human testing.

Last week I did another round of labs and for example my PSA remains unchanged at 0.5, so prostate is happy. Rest of labs look as expected with no surprises, in spite of being on a TRT++ protocol for three months + FLGR, so a worst case, or depending how you look at it, a best case (lol!) scenario.

I remain a researcher of Klotho at one vial per 13 days.

https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click on image to zoom&p=PMC3&id=13004672_41591_2026_4204_Fig2_HTML.jpg

@diegoc said:

Im doing it based off the last video they did.

1 vial was for 11 days. I split the vial and do it 1/2 vial every 7 days .

I really dont think a peptide should have degradation for 7 days mixed.

Are you just doing every 11 days?

Thanks
Diego

Gotcha. Every 12 days, one vial a-Klotho.

Side note- for research purposes I have dropped back to 5mg FLGR once per week.

@diegoc said:

@djoelcassell hey Joel.

I do klotho and i split it to 1 a week instead of every 2 weeks.

Has there been any changes were its best 2x a week?

And also i do it subq, is it better IM?

Thanks

Please be very careful with "excess" Klotho dosing, too much is said to potentially cause big problems. The inventor (75 y/o and one kidney) is being aggressive and "only" dosing a vial every 12 days instead of 14. I would respectfully suggest a vial per week is far too close to the "edge", with all risk and no benefits. Cheers friend!

I just realized I think you mean 1/2 vial per week in which case the risk of excess dose is removed, however now you have risk of degradation while half-vial is reconstituted and sits in fridge. No proof of this, just risky and expensive mistake if it does degrade.

@djoelcassell said:

@PeptidePete Yes! I have been using both for about 6 months. I honestly can't say how much I feel with the Klotho, but it's more about blood work anyway. I have better Kidney function and my blood markers show that since starting. Don't know if it's worth the money since I don't have significant health issues that Klotho would address anyway. But it is supposed to be the longevity peptide.

The FLGR 242, a different story. It has allowed me to drop Reta to a microdose since it burns fat so effectively. I'm a 61 year old man and have been on TRT for 6 years. Since taking the FLGR-242, I have put on more muscle and gotten ripped. I have always worked out and had good muscle size. Now it is a little bigger and like I said, ripped.

Klotho may be doing other amazing things that I don't see. That's why I still take it, but I am taking the FLGR 242 because of the results I can see. It's really a fantastic product! Hope that helps.

Wow! Here's to ripped "old" guys! lol

Great post, full agreement

@Stones67 said:

In an effort to get Pete's thread back on track here's some N=1 dexa data that could be interesting for those poking around FLGR:
Jan 20. Tot mass: 168.1lbs, Lean mass: 128lbs, BF 20.7%, Fat mass: 34.8lbs, Visceral Fat:1.37lbs
July 2. Tot mass: 162.2lbs, Lean mass: 136.2lbs, BF 12.9%, Fat mass: 20.8lbs, Vis Fat: 0.91 lbs
Quick math: Tot mass: -5.9lbs, Lean mass: +8.2 lbs, BF -7.8%, Fat mass: -14lbs, Vis Fat: -0.46lbs
FLGR started second week of March. Started low 1.25mg/wk for weeks 1-2, 2.5mg/2.5mg thereafter until 2 weeks ago, now 5mg/wk. Other relevant stack items: Reta, CJC/Ipa, Enclomiphene 6.25mg/day.
Are there other ways to get these results? Sure.

SWEET!

Enviable results. Congrats on the smart and hard work

Join the club, I've blacklisted them as a supplier.

They put themselves out there as the most reputable of the bunch, but I'll never buy from them again as they would not produce a CoA for 8 vials I bought. Had to go back and forth for weeks and finally authorized a return and refund after I involved the Peptide Critic himself. Used to have a stellar reputation, now a zero in my world.

@diegoc said:

That vascularity! haha I can relate!

Thankfully at now 2.5mg once weekly my wife has not developed the vascularity.

@diegoc said:

@peptidepete hey brother.

Just to go back on your journey.

How much Test are you doing and how long?

Are you doing any secretagoges or GH?

Were you lifting before FLGR?

I ask because this is my journey.

September 01, 2025 (35% BF) 159lbs
Started Low Dose Reta in November 2025
Feb 18, 2026 started (22% BF) 2iu,GH, same 160mg weekly Test, 2mg Reta weekly
3months
May 13, 2026 (15% BF) 158lbs stopped Reta same doses. Gained 12lbs of muscle.

June 15, maintained 2iu, 160mg Test C
(13.5% BF

2400 Calories
12k steps daily
4x cardio weekly 20min
4x a week Gym

What a transformation! Very nice! Congrats on all the smart, hard work! You are an inspiration for all who aspire to improve!

Similar path, Wow!

Great questions.

Test- I do one pump sublingual Oralonly.com, my prescription is 30mg/ml, one pump is 30mg. Once daily, every morning first thing subsequent to waking. So that equates to 210mg per week. No negative sides, none. Labs are perfect- SHBG very low, E2 too low (using EstroGel right now in fact!), Free test very high, no effect on Hemo/Hematocrit. Used since late Dec approx when I began FLGR. As noted, I did prescription test cyp self-IM inj years ago with crap results, certainly no vascularity or muscle gain and disaster labs.

I did GH secretagoges for approx 3 months- Ipa, Tesa, CJC-1295 WITH DAC (written up in different thread). Lab tests were great. Discontinued in approx March to begin GH at various IU doses 2-8IU (research!). Jury still out on which one prefer, I get extremity edema higher than 4IU, everyone is different for neg sides.

I have never "lifted" or even been in a gym. All I do is X3 2-3x per week, 15 min per session. I'll do 20 minute walk 2-3 days per week incorporating sprints.

I did Reta for approx Nov-Feb, it REALLY stunted my muscle growth as it did with you. But, helped get the stubborn fat off and out.

Currently I am up 14.5lbs Skeletal Muscle Mass, +21lbs Soft Lean Mass, Body Fat from 17% to 12.7% (remember I have been strict carnivore for nearly 4 years, so a good starting base), weight 155lbs to 174lbs.

Just discontinued 4 weeks or an oral AAS, still doing a oil AAS. The mildest of both at low doses. The oral gave me heartburn and reflux, glad to go off of it. First time in my life I have researched them. I might stay on the oil all year, have to see. Course these require careful monitoring and "ancillaries".