Opinion/experience on MOTS-C cycle/protocol
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@derekg1 I love methylene blue, but for folks less familiar with it, do be aware that it can raise blood pressure, and is an MAO inhibitor (so if you are taking anything that messes with your serotonin, like an SSRI, beware). The blood pressure raise isn't terrible, but if you are already hypertensive, you may need to sit this one out
@derekg1 I love methylene blue, but for folks less familiar with it, do be aware that it can raise blood pressure, and is an MAO inhibitor (so if you are taking anything that messes with your serotonin, like an SSRI, beware). The blood pressure raise isn't terrible, but if you are already hypertensive, you may need to sit this one out
High doses for sure. I monitor my rat's bp daily and so far this lower dose combo has had zero impact on his bp numbers. They actually gone down some thanks to the weight loss. But def a good call out. I figure all the mitochondrial up regulators have an outside chance of impacting bp just by "reving the engine" a bit.
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B Complex and TMG along with MOTS is a must for me! Otherwise I run into the same problem as @commander.
@Shaqdiesel What is TMG? I've been running Mots for a month and a half 3.3 MWF. I used to do daily. But my afternoons drag on the day I dose Mots. I do take a methylated B vitamin. Have been researching Ss31 for over a month also.
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@Shaqdiesel What is TMG? I've been running Mots for a month and a half 3.3 MWF. I used to do daily. But my afternoons drag on the day I dose Mots. I do take a methylated B vitamin. Have been researching Ss31 for over a month also.
@Hammertime65 trimethyl glycine? Ive been taking it for a month or two along with epicatechin and hmb and i feel as a stack they help in the gym.
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B Complex and TMG along with MOTS is a must for me! Otherwise I run into the same problem as @commander.
@Shaqdiesel
It is that special L-METHYLFOLATE (5-MTHF) FOLATE that seems to make the difference -
This post is deleted!
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@Shaqdiesel What is TMG? I've been running Mots for a month and a half 3.3 MWF. I used to do daily. But my afternoons drag on the day I dose Mots. I do take a methylated B vitamin. Have been researching Ss31 for over a month also.
@Hammertime65 TMG is recommended to anyone using NAD+ to replenish methyl groups. Methylated versions of vitamin B12 and B9 are also used for that.
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@Shaqdiesel What is TMG? I've been running Mots for a month and a half 3.3 MWF. I used to do daily. But my afternoons drag on the day I dose Mots. I do take a methylated B vitamin. Have been researching Ss31 for over a month also.
@Hammertime65 @commander (Trimethylglycine)
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So if I'm taking a methyl B complex, I should be covered once I start nad?
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So if I'm taking a methyl B complex, I should be covered once I start nad?
@Hammertime65 check yourself by testing for homocysteine levels. I brought mine down from 11-12 to 7 by using tmg etc.
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@Hammertime65 check yourself by testing for homocysteine levels. I brought mine down from 11-12 to 7 by using tmg etc.
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@vpeptides Blood test?
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@Lady-Hamilton
I personally 'researched' MOTS-C from a couple of different vendors and tried low doses, various injection sites, etc - and every time I ended up with a super unpleasant histamine reaction (beyond a local injection site response) that seemed to get worse with progressive use. MOTS-C is just not for me I guess
From what I've read, this isn't necessarily unique to me, so my advice would be to start low to gauge your tolerance first.@christexer What was your injection site(s)? Burned like crazy for me in abdominal, same as GHK-CU. I tried Upper Glutes and the pain was almost nonexistent.
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My fox has been researching with MOTS-c for about 5 weeks now. The little guy started at 200mcg and had no negative side effects for the first 2 weeks. But on the last dose of the second week started getting ISR that were pretty bad. I kept him at 200mcg past 2 weeks because of this and even reconstituted another vile (with Hospira both times) and the ISRs continued. We moved from a daily dose to a 3x per week dose, started taking Zyertec daily, and moved the injection site to the upper glute with no change. I’m considering ending my research with this pep. The benefits just aren’t out weighing the drawbacks for this particular fox.
@WesEqualshXc I collect anecdotal evidence and the amount of times I've come across similar comments all over the internet is alarming. There is also a loud group that loves this peptide, so I guess take it if you can tolerate it.
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@Hammertime65 check yourself by testing for homocysteine levels. I brought mine down from 11-12 to 7 by using tmg etc.
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@Lady-Hamilton
I personally 'researched' MOTS-C from a couple of different vendors and tried low doses, various injection sites, etc - and every time I ended up with a super unpleasant histamine reaction (beyond a local injection site response) that seemed to get worse with progressive use. MOTS-C is just not for me I guess
From what I've read, this isn't necessarily unique to me, so my advice would be to start low to gauge your tolerance first.@christexer once you have correct dosage in syringe, add BAC water to the syringe to dilute it.
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I am currently taking 2mg 3x week ( working up to 3.3mg ). I do this preworkout in the AM, and try to target cardio days. I know I've taken it as I start sweating a little earlier in my workout than normal. No heart rate increase or higher breath rate, it's just like Im a little more warmed up when I start my workout.
Also taking ( buffered ) NAD - I find ( at least for me ) that NAD has a more energizing effect.
Definitely would not take MOTS-C in the late afternoon/evening ( before sleep ).
I did get a skin reaction at first. I backed the dosage down and added more BAC water.
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@hammertime65 - I could be incorrect but I believe the methyl groups getting diminished by NAD was if you are taking oral NAD. Your liver adds chains to the NAD that it doesn't immediately absorb before releasing it for the rest of the body, and the rest of your system can deplete methyl groups getting the NAD back to a state where it can be used by the cells.
Injected NAD bypasses the liver.
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@hammertime65 - I could be incorrect but I believe the methyl groups getting diminished by NAD was if you are taking oral NAD. Your liver adds chains to the NAD that it doesn't immediately absorb before releasing it for the rest of the body, and the rest of your system can deplete methyl groups getting the NAD back to a state where it can be used by the cells.
Injected NAD bypasses the liver.
@dogwalker (checked with AI)
While injecting or infusing NAD+ bypasses liver "first-pass" metabolism to raise blood levels quickly, your body must still degrade and recycle the excess.The Methylation Process: When excess NAD+ or its byproduct, Nicotinamide (NAM), circulates, the body upregulates an enzyme called NNMT (Nicotinamide N-methyltransferase). This enzyme safely disposes of excess NAM, but doing so requires methyl donors (primarily SAM-e, which provides the methyl group) to create MeNAM.
The Result: If large, therapeutic doses of NAD+ are administered, this continuous excretion process can drain the body's methyl pool.
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Take TMG!
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