Tesamorelin Research Dosing Protocol
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For research use only. Not medical advice.
Overview
Tesamorelin is a synthetic 44–amino acid GHRH analog that stimulates endogenous GH release and raises IGF-1 levels.
It is FDA-approved for reducing visceral fat and is widely researched for body composition, metabolic enhancement, and aging-related applications.
Most research follows the standard 2 mg once-daily subcutaneous protocol.Daily Dosing Protocol (Subcutaneous)
Standard Daily Dose
2 mg once daily
Administered consistently at the same time each day (often in the evening to align with nocturnal GH rhythms).
Optional Titration Schedule
Some researchers prefer to begin with a short ramp to improve tolerability.
Week 1
1 mg daily
Weeks 2–12+
2 mg daily
This is the typical working and maintenance dose used in clinical and research settings.
Cycle Length
While Tesamorelin can be used continuously, the most common research patterns are:
8–12 weeks on protocol, followed by
2–4 weeks off, then repeat as needed.
Longer continuous use (12–24+ weeks) is also documented in research settings.
Alternate Timing Strategies
Although daily evening administration is the classic model, researchers may use morning Dosing
Chosen when subjects report improved energy or reduced nighttime hunger signals.
Split Dosing
1 mg twice daily
Used occasionally to blunt injection-site reactions or flatten GH spikes.
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I’ve been taking Tesamorelin for 2 weeks—1 mg during the first week and 2 mg at night during the second week. I inject it about 30 minutes before bed, with no food for at least 3 hours beforehand.
Since starting it, my nighttime heart rate has increased. My average resting heart rate used to be around 60, but recently it’s been 86, 70, and 69. My stress levels have been very high, I’m not getting any REM sleep, and I’m having trouble sleeping overall.
I know that this is an evening Peptide, but would AM hour work better maybe? I could pause for a couple of days and see if my heart rate and sleep normalize also. -
Thank you sir....
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Thoughts on doing a Tesa/Ipa protocol? I was watching a video yesterday talking about doing that with a morning injection schedule to take advantage of overnight fasting and then not eating for a few hours. This would work well for intermittent fasting regimens, might help with sleep, and is supposed to be better for shredding.
I just finished a CJC/IPA cycle and between the challenge of fasting (I don’t get home til after 9 a lot) and not sleeping great on it, I’m thinking about alternatives down the road. CJC/IPA definitely works for me but might not be ideal, and sermorelin is quite subtle.
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Thoughts on doing a Tesa/Ipa protocol? I was watching a video yesterday talking about doing that with a morning injection schedule to take advantage of overnight fasting and then not eating for a few hours. This would work well for intermittent fasting regimens, might help with sleep, and is supposed to be better for shredding.
I just finished a CJC/IPA cycle and between the challenge of fasting (I don’t get home til after 9 a lot) and not sleeping great on it, I’m thinking about alternatives down the road. CJC/IPA definitely works for me but might not be ideal, and sermorelin is quite subtle.
@ResearchCat.... I've been on the Tesamorelin and Ipamorelin injections for several wks now so far with EXCELLENT results.... I do (2) injections daily of Ipamorelin....0.25mg of Ipamorelin dose in the mornings (fasted before breakfast) and another 0.25mg dose of Ipamorelin at night before bed for 5 days a wk.
The Tesamorelin I take just once nightly at a 2mg dose before bed for 5 days a week.
Saturday and Sundays are my days off
Hope this helps answer your question. -
@ResearchCat.... I've been on the Tesamorelin and Ipamorelin injections for several wks now so far with EXCELLENT results.... I do (2) injections daily of Ipamorelin....0.25mg of Ipamorelin dose in the mornings (fasted before breakfast) and another 0.25mg dose of Ipamorelin at night before bed for 5 days a wk.
The Tesamorelin I take just once nightly at a 2mg dose before bed for 5 days a week.
Saturday and Sundays are my days off
Hope this helps answer your question.@TShivers said in Tesamorelin Research Dosing Protocol:
@ResearchCat.... I've been on the Tesamorelin and Ipamorelin injections for several wks now so far with EXCELLENT results.... I do (2) injections daily of Ipamorelin....0.25mg of Ipamorelin dose in the mornings (fasted before breakfast) and another 0.25mg dose of Ipamorelin at night before bed for 5 days a wk.
The Tesamorelin I take just once nightly at a 2mg dose before bed for 5 days a week.
Saturday and Sundays are my days off
Hope this helps answer your question.Did you start at 2mg and .5mg or did you titrate up to that level?
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P PeptideCritic moved this topic from Growth & Performance on
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Starting tesa tomorrow. Going with 1mg fasted in am tomorrow to see how that goes.
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@randy Totally off-topic, but is there any way you can add a new vendor to the Vendor Directory? I recently placed an order with ngpeptide.com and’d like to leave a review. I’ve heard good things about them, so yeah just a suggestion, lmk what you think!
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Hey friends, @randy might have opined on this also, but curious to hear what others think. I saw another video that nightly tesamorelin might be impacted for those taking Tirz or Reta due to slowed gastric emptying, meaning that folks are not as truly fasted and still carrying heavier insulin when they poke before bed.
I like Tesamorelin/ipa at nights due to restful and deeper sleep (even with toddlers), but I am on tirz and try to have my last bite 3 hours before bed. Not sure if eating dinner 4 hrs before is doable..
Curious to hear your thoughts about a morning routine instead? For you morning folks, do you just wait at least 30 mins before a pre workout? I was gonna try Tesa at night and Cjc in the morning but might be reconsidering this to not have duplicative secretagogues at the same time. Ty! -
I am researching Tirz and have cycled sermorelin and CJC/Ipa, fasting 2 hours before, and it works. Don’t let the perfect be the enemy of the good.
Currently pinning tesa right when I get up and trying to fast for 2 hours after because I get home late and fasting 2-3 hours before bed makes it hard to hit my macros. Will let you know in a few weeks how it’s working.
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Hey friends, @randy might have opined on this also, but curious to hear what others think. I saw another video that nightly tesamorelin might be impacted for those taking Tirz or Reta due to slowed gastric emptying, meaning that folks are not as truly fasted and still carrying heavier insulin when they poke before bed.
I like Tesamorelin/ipa at nights due to restful and deeper sleep (even with toddlers), but I am on tirz and try to have my last bite 3 hours before bed. Not sure if eating dinner 4 hrs before is doable..
Curious to hear your thoughts about a morning routine instead? For you morning folks, do you just wait at least 30 mins before a pre workout? I was gonna try Tesa at night and Cjc in the morning but might be reconsidering this to not have duplicative secretagogues at the same time. Ty!@jborja said in Tesamorelin Research Dosing Protocol:
Hey friends, @randy might have opined on this also, but curious to hear what others think. I saw another video that nightly tesamorelin might be impacted for those taking Tirz or Reta due to slowed gastric emptying, meaning that folks are not as truly fasted and still carrying heavier insulin when they poke before bed.
I like Tesamorelin/ipa at nights due to restful and deeper sleep (even with toddlers), but I am on tirz and try to have my last bite 3 hours before bed. Not sure if eating dinner 4 hrs before is doable..
Curious to hear your thoughts about a morning routine instead? For you morning folks, do you just wait at least 30 mins before a pre workout? I was gonna try Tesa at night and Cjc in the morning but might be reconsidering this to not have duplicative secretagogues at the same time. Ty!I only research my GHRH/GHRP peptides in the a.m., first thing fasted now, for a whole bunch of reasons. It's just easier and more convenient for me, I know I'm totally fasted with insulin at its lowest point (and therefore getting the strongest amount of receptor saturation as possible).
Plus I'm just more awake/alert in the a.m., easier to pin and reconstitute if need be. I spent many late nights in years past pinning/researching before bed after a long day and when tired, it's just difficult.
I wait 2 hours before eating anything. I drink black coffee right away in the morning after pinning and the combo of peptides, coffee and being fasted in the a.m. is a superpower for getting stuff done. Plus I find GH peptides stimulating in a way in the morning.
I like the idea of going natural at night (no GH peps) and really letting my natural production do its thing. I have found that there must be some carry over anyways, because on cycle my rat sleeps better even though he pins in the a.m only.
Rather than trying to find a way to squeeze in Tesa/CJC in the same day, I'd recommend you use one or the other during your cycle. You can flip flop them as well, going back and forth when one vial runs out.
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Want to give a shoutout to Tesa from a 60-year-old male. I have been injecting 1mg Sun-Thurs for 12 weeks (among other things including Testosterone, Reta, GHK-Cu and Semax/Selank). Scan from yesterday showed a drop in visceral fat from 112 cm² to 70.3 cm² (37% reduction). Obviously, the Testosterone and Reta played a part, but I can definitively say it helped me. I'm a big fan. I'm taking a 2-week break and will start another cycle again. Can't say enough good things.
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I left a review for crush when they weren’t listed because I understood it to be open. Think they get added based on reviews?
@WisGal64 oh really? I deleted my post because it didn’t have a tag for the vendor. But I’ll re-upload it
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Thoughts on doing a Tesa/Ipa protocol? I was watching a video yesterday talking about doing that with a morning injection schedule to take advantage of overnight fasting and then not eating for a few hours. This would work well for intermittent fasting regimens, might help with sleep, and is supposed to be better for shredding.
I just finished a CJC/IPA cycle and between the challenge of fasting (I don’t get home til after 9 a lot) and not sleeping great on it, I’m thinking about alternatives down the road. CJC/IPA definitely works for me but might not be ideal, and sermorelin is quite subtle.
@ResearchCat I was doing my second vial of chc/ipa and was really loving the sleep and recovery. I heard a video of adding tesamoreline so added .5 mg then stopped the cjc and was doing 1 mg of Tesa at night for a week. I had one more dose left but I tossed it.
My back got sore, my joints were stiff and it felt like tesa was working completely against my recovery stack.
Last night, my sleep wasn’t as good and needed to take a KPV to help with all that inflammation. I also ate some yogurt which hunger seems to be working against the body composition goals. Im going to the hotsprings, taking the weekend off and may restart my cjc/ipa Monday night. I also did a BPC 157 this morning with another KPV, which is helping. Tesa is NOT for me… -
Well, all this just kinda blows me out of the water. I need to get rid of a lot of visceral fat; I mean A LOT. The DEXA was horrible! I'm not that overweight, but the Dr. said, and I concur, it's been there a long time and I was raised on a Southern diet. I'm currently taking Tirzep once/wk on Friday night; nothing to eat since lunch, except very light snack later so stomach's not growling. NAD+ M,W & Sat, mornings upon waking, approx 10 hour fast. I have trouble sleeping and get up at 4:30, so not sure where to fit in Tesa. Question for all, but esp. for @randy Do Tesa and NAD+ work well together? I can cut back on the NAD, but not the Tirzep. I could also stay on lower does of Tesa for longer. What do y'all think?
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M.D.? Someone mentioned somewhere on this blog that all the influencers out there are DC's or anything other than MD's. Maybe this one is MD? Got to go to work right now but will look up licensing this weekend.
https://youtu.be/Ky5Hodz3-9A?si=P0iLJhekK0GujTSo -
What is the NAD+ for? I don’t know your history or goals, but almost think that MOTS-C might be more effective if you are trying to burn fat, especially if you are exercising.
I see no issues researching NAD+/MOTS-C with a GHRH. You can research Tesa/Ipa/CJC first thing in the morning fasted or an hour before bed after fasting 2-3 hours.
I am not a doctor, or your doctor, but I like to have a specific goal and purpose for whatever peptides I am researching, even if I am researching several at the same time. ;). At the moment, I am much more bullish on MOTS-C than on NAD+ as part of an ongoing maintenance stack.
