Tesamorelin Research Dosing Protocol
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Just a quick update. I don’t know with certainty that it is from the Tesa, but since starting research, I have noticed not that my hands are swollen, but that they feel kind of swollen, if that makes sense, and my thumbs and wrists have been pretty sore. I’ve generally had more joint soreness as well despite continued KLOW research. I will give it another couple weeks but am likely going to accelerate the move back to CJC/Ipa, which was working very well for me.
@ResearchCat I don't have any experience on Tesa but I've read and talked to people that said it causes water retention and sometimes joint pain.
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Im really struggling with Tesa over CJC. It requires much higher dosing (like 8x more expensive just based on 250mcg vs 2mg dosing), is less stable in the vial from what I gather, and essentially does the same thing.
Is it the FDA approval? I know it is hailed as the 'visceral fat' pick for these GHRH analogs but the reason for that is because it was tested for it...the others are going to do the same thing, which is getting the downstream IGF-1 boost.
What am I missing?
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Nope, you nailed it. People do it for the visceral fat. IMO, If you tolerate it well, CJC/IPA is the answer.
100% Natty. You know, aside from the Klow, Tesa, Tirz, CJC/Ipa, SS-31, Semax, Dihexa, Epitalon, MOTS-C, creatine, Cheetos, protein shakes, and a holocaust of chicken thighs.
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Nope, you nailed it. People do it for the visceral fat. IMO, If you tolerate it well, CJC/IPA is the answer.
@hunt_ak Tesamorelin is claimed to be effective for visceral fat because it was FDA-approved for that purpose, so there were studies confirming it. But all it is - a slightly modified 44-amino-acid Growth Hormone-Releasing Hormone (GHRH). CJC-1295 is also, a slightly modified 29-amino-acid fragment of the same GHRH hormone (while Sermorelin is 1-29 unmodified fragment, btw). So, it's smaller, which means more molecules per mg, and it may be as effective in smaller doses. CJC-1295 wasn't tested for visceral fat as much as Tesamorelin, not that it would fail the testing. It could be as effective or even more effective than Tesamorelin, we just don't have the trials.
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I saw an influencer state that due to the length of the amino chain structure of Tesa being longer than most peptides, that it should be stored at room temperature and used within 7 days. He was saying that due to the length it has a tendency to fold on itself, and refrigeration makes that more likely. Sounded convincing, but so does a lot of things that aren't necessarily true.
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@hunt_ak Tesamorelin is claimed to be effective for visceral fat because it was FDA-approved for that purpose, so there were studies confirming it. But all it is - a slightly modified 44-amino-acid Growth Hormone-Releasing Hormone (GHRH). CJC-1295 is also, a slightly modified 29-amino-acid fragment of the same GHRH hormone (while Sermorelin is 1-29 unmodified fragment, btw). So, it's smaller, which means more molecules per mg, and it may be as effective in smaller doses. CJC-1295 wasn't tested for visceral fat as much as Tesamorelin, not that it would fail the testing. It could be as effective or even more effective than Tesamorelin, we just don't have the trials.
@vpeptides This is exactly how I understand it as well. I'm in camp CJC for now!
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I saw an influencer state that due to the length of the amino chain structure of Tesa being longer than most peptides, that it should be stored at room temperature and used within 7 days. He was saying that due to the length it has a tendency to fold on itself, and refrigeration makes that more likely. Sounded convincing, but so does a lot of things that aren't necessarily true.
@50PLUSFIT I also believe this to be true based on the anecdotal evidence I've seen of friends and online people running into issues with refrigerating Tesa. I've not seen any reports of CJC 'going cloudy' or whatever but many with Tesa
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I have been using Tesa for 4 months straight now. No issues whatsoever. No cloudiness, no gelling, nothing. I take 1.5mg to 2mg every night. My mixed Tesa is stored in the fridge same as all the rest. I mix a 30mg cart (30mg Tesa in 3ml bac), that cart lasts me 15 to 20 days. Tesa makes me sleepy… and it doesn’t loose that effectiveness at all for the whole cart. So take it for what it is worth.
Additionally, I have definitely lost a decent amount of visceral fat on it. I had a dexa scan just before starting it, my stomach protruded a lot (Like a Navy Chief
). Now it doesn’t at all. I am due for another dexa scan soon to see the actual hard numbers. I don’t use those shit scales because they are not accurate. Take it for what it is worth. -
I have been using Tesa for 4 months straight now. No issues whatsoever. No cloudiness, no gelling, nothing. I take 1.5mg to 2mg every night. My mixed Tesa is stored in the fridge same as all the rest. I mix a 30mg cart (30mg Tesa in 3ml bac), that cart lasts me 15 to 20 days. Tesa makes me sleepy… and it doesn’t loose that effectiveness at all for the whole cart. So take it for what it is worth.
Additionally, I have definitely lost a decent amount of visceral fat on it. I had a dexa scan just before starting it, my stomach protruded a lot (Like a Navy Chief). Now it doesn’t at all. I am due for another dexa scan soon to see the actual hard numbers. I don’t use those shit scales because they are not accurate. Take it for what it is worth.@Commander Commander not sure if you tried the Hume. I just got a Dexa scan, and it's pretty much the same as the Hume that was nice to see. I need to try Tesa for my handles, I swear its bone on those sides they will not away.
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@Commander Commander not sure if you tried the Hume. I just got a Dexa scan, and it's pretty much the same as the Hume that was nice to see. I need to try Tesa for my handles, I swear its bone on those sides they will not away.
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I have been using Tesa for 4 months straight now. No issues whatsoever. No cloudiness, no gelling, nothing. I take 1.5mg to 2mg every night. My mixed Tesa is stored in the fridge same as all the rest. I mix a 30mg cart (30mg Tesa in 3ml bac), that cart lasts me 15 to 20 days. Tesa makes me sleepy… and it doesn’t loose that effectiveness at all for the whole cart. So take it for what it is worth.
Additionally, I have definitely lost a decent amount of visceral fat on it. I had a dexa scan just before starting it, my stomach protruded a lot (Like a Navy Chief). Now it doesn’t at all. I am due for another dexa scan soon to see the actual hard numbers. I don’t use those shit scales because they are not accurate. Take it for what it is worth.I have been using Tesa for 4 months straight now. No issues whatsoever. No cloudiness, no gelling, nothing. I take 1.5mg to 2mg every night. My mixed Tesa is stored in the fridge same as all the rest. I mix a 30mg cart (30mg Tesa in 3ml bac), that cart lasts me 15 to 20 days. Tesa makes me sleepy… and it doesn’t loose that effectiveness at all for the whole cart. So take it for what it is worth.
Additionally, I have definitely lost a decent amount of visceral fat on it. I had a dexa scan just before starting it, my stomach protruded a lot (Like a Navy Chief). Now it doesn’t at all. I am due for another dexa scan soon to see the actual hard numbers. I don’t use those shit scales because they are not accurate. Take it for what it is worth.This is great info, thanks for posting. 20 days on fridged Tesa and no issues with continued effectiveness.
How old is your rat?
What does his cycle look like (or will look like?) You mentioned 4 months into it, what do you have planned for this moving forward?
Do you have any IGF-1 lab numbers?
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I have been using Tesa for 4 months straight now. No issues whatsoever. No cloudiness, no gelling, nothing. I take 1.5mg to 2mg every night. My mixed Tesa is stored in the fridge same as all the rest. I mix a 30mg cart (30mg Tesa in 3ml bac), that cart lasts me 15 to 20 days. Tesa makes me sleepy… and it doesn’t loose that effectiveness at all for the whole cart. So take it for what it is worth.
Additionally, I have definitely lost a decent amount of visceral fat on it. I had a dexa scan just before starting it, my stomach protruded a lot (Like a Navy Chief). Now it doesn’t at all. I am due for another dexa scan soon to see the actual hard numbers. I don’t use those shit scales because they are not accurate. Take it for what it is worth.@Commander Same. I am on my second cycle and no issues at all for me. Each vial is used for 2 weeks, no cloudiness or gelling at all. And it is effective. I have lost significant amount of visceral fat measured by body scan.
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Im really struggling with Tesa over CJC. It requires much higher dosing (like 8x more expensive just based on 250mcg vs 2mg dosing), is less stable in the vial from what I gather, and essentially does the same thing.
Is it the FDA approval? I know it is hailed as the 'visceral fat' pick for these GHRH analogs but the reason for that is because it was tested for it...the others are going to do the same thing, which is getting the downstream IGF-1 boost.
What am I missing?
Im really struggling with Tesa over CJC. It requires much higher dosing (like 8x more expensive just based on 250mcg vs 2mg dosing), is less stable in the vial from what I gather, and essentially does the same thing.
Is it the FDA approval? I know it is hailed as the 'visceral fat' pick for these GHRH analogs but the reason for that is because it was tested for it...the others are going to do the same thing, which is getting the downstream IGF-1 boost.
What am I missing?
You're not missing anything. The same reason why Tesa burns visceral fat is the same reason why CJC does - GHRH --> GH --> IGF-1
The reason why Tesa is a thing is entirely because it was modified slightly so they could patent and sell it for profit, as they couldn't do that with CJC-1295
The main difference is that CJC-1295 is much stronger and has a slightly longer half life, which means it must be dosed at a much careful/supervised amount, and there is less wiggle room for side effects. Meaning, theoretically, with Tesa you're likely to have more wiggle room for dosing experimentation across a wide range of people and less likely to run into issues given.
You can have a blanket recommendation of say 1mg per day of Tesa as a starting dose and 150mcg of CJC-1295. Because Tesa has a shorter half life and doesn't illicit as strong of a GHRH response, it's likely going to be safer across a population of thousands of people using the drug.
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Im really struggling with Tesa over CJC. It requires much higher dosing (like 8x more expensive just based on 250mcg vs 2mg dosing), is less stable in the vial from what I gather, and essentially does the same thing.
Is it the FDA approval? I know it is hailed as the 'visceral fat' pick for these GHRH analogs but the reason for that is because it was tested for it...the others are going to do the same thing, which is getting the downstream IGF-1 boost.
What am I missing?
@hunt_ak
Dr Ashley Froese did a YouTube video about tesamorelin a few weeks back that I thought contained some decent information. Its called: Dr Amazed - Tesamorelin DECIMATES Visceral Fat and MORE
There does appear to be some science behind why tesa targets visceral fat better vs CJC or sermorelin beyond the IGF-1 increase, if that is your primary goal.
Is it worth the extra $$ and potential side effects - that really varies. Everyone reacts differently to peps. I personally did not like tesa at all, but others love it. -
@hunt_ak
Dr Ashley Froese did a YouTube video about tesamorelin a few weeks back that I thought contained some decent information. Its called: Dr Amazed - Tesamorelin DECIMATES Visceral Fat and MORE
There does appear to be some science behind why tesa targets visceral fat better vs CJC or sermorelin beyond the IGF-1 increase, if that is your primary goal.
Is it worth the extra $$ and potential side effects - that really varies. Everyone reacts differently to peps. I personally did not like tesa at all, but others love it.@hunt_ak
Dr Ashley Froese did a YouTube video about tesamorelin a few weeks back that I thought contained some decent information. Its called: Dr Amazed - Tesamorelin DECIMATES Visceral Fat and MORE
There does appear to be some science behind why tesa targets visceral fat better vs CJC or sermorelin beyond the IGF-1 increase, if that is your primary goal.
Is it worth the extra $$ and potential side effects - that really varies. Everyone reacts differently to peps. I personally did not like tesa at all, but others love it.Another caveat I forgot to mention above, in that I do like Tesa for the simple fact that I always like to cycle my GHRH analogs to prevent potential antibody response. I do like to have complete down time with no exogenous GHRH usage, but I also like to cycle various GHRH peptides in and out. So it's nice to have another option in Tesa alongside CJC-1295 and Sermorelin.
As far as Tesa vs. CJC-1295 and the purported science behind why Tesa burns visceral fat better, I don't believe that it does at all and I haven't seen any science or evidence that proves that. I'll check out Dr. Ashley's video out and see what she has to say.
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12 weeks did me very well. I am currently just finishing week 6 of a planned 16 week cycle. You do have to be patient but you will see results if you have all the other things dialed in.(diet, exercise, sleep)
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