Peptide Critic Community

well i'm not saying that it isn't also marketing. that's obvious and its working for them. like selling bottled water... everyone is arguably selling the same product.

@MyB be more specific with your question.

you can just look up the Molecular Weight (Da) of any peptide online yourself.

Peptide Approx. Molecular Weight (Da)
examples:

Glutathione ~307
Noopept ~251
KPV ~400
Pinealon ~404
Epithalon ~488
Semax ~751
Selank ~752
TB-500 (fragment) ~889
GHK-CU ~909
AHK-CU ~900-950
PE-22-28 ~900 (estimated)
DSIP ~1,000 (borderline)

Just to be clear: peptides that are >1000 Daltons can still be made to work in spray form like Melanotan II ~1,024 (Da) but they need permeation enhancers to be effective.

you can't just use BAC water on any peptide mix it up and spray expecting results.

the closer you get to 1000 the less effective they will be.
Pinealon, Epithalon, Semax and Selank are widely "researched" intranasally because of their low molecular weight.

@MyB you'll lose some yes. stick with PES (Polyethersulfone) not nylon or anything else. for all the hassle just get the right filters and make life easier.

@gym.rat it's just alcohol and water. you'd think it wouldn't make any difference. but the manufacturers say on the bottle "do not freeze" ... so just throw it. it probably loses it's bacteriostatic effect.

@MyB said:

Technically anything with a Dalton weight under 500 will work.

The 500 Da limit is about crossing from the bloodstream into the brain (the Blood-Brain Barrier, or BBB).

1,000+ Da is still possible when we are talking about crossing from the nasal cavity into the brain/body (the nasal mucosa and the nose-to-brain pathway).

that's why things like MT2 which is over 1000 Da still work.

when you say "only up to 500 Da," you are thinking of injected peptides trying to cross the BBB.

peptides >1,000 Da still work intranasally, we are talking about sprayed peptides using the nose-to-brain pathway.

@TrueNorth that's why you should always filter peps. how do you know if the problem is with the MOTS-c or the BAC water? use Hospira BAC and if it's still cloudy it's the MOTS-c. if it's clear then the problem was with your China sourced BAC water.

@EstrogenDragonLover said:

I have reconstituted Adamax,

how did you reconstitute Adamax for intranasal absorption?
Adamax is 1,800-2,000 Da and anything over >1000 Daltons cannot cross the blood brain barrier simply with BAC/Saline/Distilled water alone.

so i want to know how you did it.

@pmcelveen said:

If so, what is the best filter specs for BPC & TB?

for all peptides:
Sterile PES syringe filter: 4mm 0.22 μm (filtration for 1-2ml)
Sterile PES syringe filter: 13mm 0.22 μm (filtration 2-10ml)

make sure they say sterile on the box and are individually sealed.
make sure the filtration membrane is PES. "polyethersulfone."
only use once and throw away. buy a box of 50-100pcs for convenience.

@Stevepep from what i can tell a drop is just a batch that they were waiting on the test results to be released. everyone wants the purity and safety. so the "drops" sell out because they are genuinely getting tested not faking COAs like some do.