@StudzPeptides I’ve made several purchases from these guys now and everything I’ve received has been top notch. I know people have their preferences when it comes to labs, but whether the testing was through Freedom, ILS, or now increasingly more Vanguard, my experience with the products has been great.

Seeing them consider adding sterility, endotoxin, and conformity testing through Vanguard would pretty much close that last 1% of hesitation left for me.

I also appreciate that they actually listen to the community and continue improving rather than just chasing the cheapest option.

Love what these guys are doing for the community.

Here is their Discord if anyone wants to follow along with the changes and community.

https://discord.gg/7f5MydZxF

@BeeKind My Cag research has been going extremely well! I'm currently at 266 mcg, strange number I know, but that's just how the math worked out reconstituting 10 mg with 3 mL. Started at 100 mcg, moved to 200, and now 266. I think I've found my sweet spot and plan on staying here. It's accomplished exactly what I wanted, quieting those evening cravings and the constant urge to snack. Definitely a powerful addition alongside Reta!

With the littles in soccer season, we're constantly on the go, which means quick food decisions that aren't always the healthiest. Even with that, the weight continues coming off consistently each week. Low and slow is my approach. I'm not looking to drop weight overnight and end up with a bunch of loose skin. I'd rather give my body time to adjust along the way. So far, I'm extremely happy with the results! Appreciate you following up

@MikeMiranda Little update on my Reta/Cag journey! I'm still consistently dropping around 1.5lbs a week and heavily enjoying the combination. Even better, my recent bloodwork showed positive improvements in my A1C! Those warning signs of prediabetes I was experiencing seem to be fading, so it's pretty damn exciting seeing the numbers moving in the right direction too!

I'll be making a slight increase from 266mcg to 300mcg of Cag this evening. Nothing crazy, just seeing how the combination continues treating me.

All in all, still loving the combination, and seeing those A1C improvements makes it that much sweeter!

@Eleanor Oh my, I have also experienced this unfortunate side effect!! Conveniently, I've remained strong in my justification and excuse department for one's actions Much easier to justify when you feel better each round, I will say.

This one is worth a read. A new 2026 Nature Metabolism study looked specifically at cagrilintide + retatrutide and found some interesting synergy beyond what you might expect from simply stacking appetite suppression.

Study setup:
Obese male rats were given Cagri, Reta, or the combination. The researchers also compared Cagri + Reta against Cagri + semaglutide and Cagri + tirzepatide.

Core protocol:
• Cagri: 5 nmol/kg/day
• Reta: 5 nmol/kg/day
• Subcutaneous administration
• Approximately 2 weeks depending on the experiment
• Additional dose-response testing from 0.3–30 nmol/kg

Results:
Cagri + Reta produced greater reductions in body weight and food intake than either compound alone at matched molar doses.

But the pair-fed experiment is what really caught my attention.

Researchers included animals restricted to the same food intake as the Cagri + Reta group, along with calorie-restricted animals used to separate the effects of reduced intake and weight loss from the pharmacology itself.

The combination still produced metabolic and molecular changes that weren't completely explained by eating less.

That's interesting because Cagri often gets viewed simply as an additional appetite suppressant alongside Reta.

Mechanistically, you're combining:

Reta → GLP-1 + GIP + glucagon receptor activity
Cagri → amylin-receptor activity

Together, researchers observed changes involving central energy-balance pathways and peripheral bioenergetic/metabolic pathways, along with improvements in markers including insulin, triglycerides and total cholesterol.

The study also found the Cagri + Reta combination produced stronger weight-loss effects than the Cagri + semaglutide and Cagri + tirzepatide combinations tested.

Big takeaway for me:
Cagri + Reta may be considerably more interesting than simply “Reta with extra appetite suppression.” The pair-fed data suggest complementary metabolic effects that extend beyond calorie reduction alone.

Study: Cagrilintide and retatrutide combination therapy enhances weight loss and metabolic outcomes in obese male rats — Nature Metabolism, 2026.

That pair-fed experiment is the part I'd really like to hear everyone's thoughts on. As well as the possibility of using it alongside reta to achieve results quicker and with more price efficiency.

had ChatGPT summarize this.

Why I had chat summarize: #1 being time of course... as well as having just purchased Cag to stack in with reta. In my endeavours I experienced a run in with a fellow researcher claiming adding cag and lowering reta was a profoundly stupid idea. 2 days later this study is dropped and proves that it may indeed be worth researching as it has not only showed greater results when combined it also will help to limit my expenditures on Reta.

@BeeKind So far, Cag is definitely doing its job in the food department. Previously I was a pretty habitual boredom eater. Now I’ll still wander into the kitchen out of habit, but then... nothing sounds good. I’m hoping over the course of this experiment I can turn that into a more structured habit instead of just relying on the appetite suppression.

Side-effect wise, I noticed a temporary uptick in flatulence probably around 12 hours after administration. It didn’t last very long. My personal thought is that my body may simply be reacting to the change and adjusting, but obviously too early to know.

One thing I’m especially interested in tracking: I’ve been walking the line with prediabetes and had started losing sensation in both big toes. Since being on Reta, the right has pretty much returned to normal, while the left has remained stubborn. Since adding Cag, I’m already noticing a little more sensation and less tingling in the left. Way too early to say Cag caused that, but it’s exciting enough that I’ll definitely be watching it.

The other strange sensation I’ve noticed is occasional warmth along the side of my right calf—almost like I’m sitting next to a heater. It comes and goes and hasn’t really bothered me, but it’s another thing I’m tracking.

Weight-wise, I baselined at 232.6 lbs on the 21st, so we’ll see shortly whether there’s been any significant movement.

I also deliberately started with a small dose because if Cag and I weren’t going to be friends, I’d rather not find that out by feeling like absolute shit for several days . So far though, the experience has been pretty smooth. Thank you for inquiring

@bfuller He developed arthritis in his back hips pretty young, so I’ve had him on glucosamine/chondroitin for years, but he was still steadily declining with age.

About 3 years ago he suddenly became paralyzed from what we assumed was a compressed nerve. We were told he’d never walk again, but we refused to give up and eventually got him back on his feet.

More recently he was really slowing down—laying around a lot, legs shaking at rest, struggling with the 4 stairs to our porch, and an exciting or active day could mean 2–3 days of sleeping and recovering.

We’re about a month in now and the difference has been pretty spectacular. His stance is broader and more solid, he gets up from laying down much easier, and yesterday he actually had me jogging on our walk . It wore him out for a day, then he was right back at it.

He still occasionally waits for help up the stairs, but I’d say that’s decreased by at least half. I’m not claiming a cure or recommending it for anyone else’s dog, but for Kodah, I’m extremely happy with what I’ve observed so far.

@pep_researcher I can relate to this one. My wife started on tirz which eventually led us to Reta that was definitely my gateway into the peptide rabbit hole too. One minute you’re researching weight loss, next thing you know you’ve got a fridge full of “research” and a browser history that needs explaining. At least we’re saving on groceries right that is true

@pep_researcher I’m with you on BPC-157/TB-500. I’ve been impressed with those as well. I’m also a big fan of KLOW because of the KPV/GHK-Cu addition. Personally, it seems to settle some of the stomach issues I get from GLP-1s, and I’ve noticed a difference in my stretch marks too. I got fat faster than my skin could keep up , so anything that helps their appearance gets my attention.

MOTS-C has actually been different for me though. That one really showed itself during cardio. I noticed I could sustain harder work on the stair stepper longer than my normal baseline, which was pretty hard for me to ignore.

SS-31 is an interesting one. I wonder if part of why some people feel absolutely nothing from it is that their mitochondrial function is already in pretty good shape to begin with. Could potentially explain why it felt like an expensive donation to the BAC-water industry for you .

@DarkStar "my virginity" bro! so rough! Sorry you had to experience these feelings

yes definitely seconding the water. I was also advised to drink more water. Back to back high gravity in urine analysis trace oxatale crystals in the 2nd. So to avoid a kidney stone doc said drink more water. Its all I consume already, so im just gonna go drown myself that should suffice, right!!

First urine test popped bilirubin and trace blood so wanted to recheck then found oxalate crystal, but no bilirubin or blood so gotta wonder if peps can trigger false positives?

Now for the good news I am no longer pre diabetic I truly award this to Reta and also cannot help but feel Cag also played a hand while in conjunction.

@DocCherie Might it let me respond here?? Prime example, My apologies Doc have been attempting a response since you wrote but due to the downvotes I recieved for my opinions about Studz, it has made it to where I cannot respond to DMs.... It hits me with a red lettered "warning" saying I need 0 reputation to respond. I appreciate your message hopefully I'll find my way into good graces here. I was only attempting to relay my successful experience. I am happy to see multiple people have since placed orders and have had similar results as myself. Hope in time that will lead to my vindication. 4th time writing up a response.... Hopefully it will allow this method of messaging to go through....

Just get them as you need them. As stated by OP there is always some type of sale going on. Trust!! We will truly know when Crap(for lack of better verbage ) truly hits the fan, Especially with the multiple forums and chat groups. Luckily haven't experienced price changes with my supplier. I have however seen name changes, which makes sense make yourself less searchable on such a vast network as the WWW..... Welp no one asked but theirs my 2 cents. great topic IMO

@Stevepep Heard and done, now that I can post again. I guess I should have waited to post my experience. I felt the first couple reviews of (dare I say the name) seemed way to enthusiastic. I went and saw the pricing the coa and them responding openly here and pulled the trigger knowing by using my CC I could chargeback if needed. It was a complete risk on my end and was sweating bullets through out the process, but I'd been paying $3/mg so wasnt going to miss out on $1/mg, hence risking it for the biscuit. When my package actually arrived and everything checked out. I had my chatgpt write up a review, as I am punctuationally challenged... hopefully getting better, as I personally typed this to appear less "bottieeee" ‍️ I truly wanted to explain my experience in detail to assure others. Guess I over shot the mark there. I also mentioned to follow the general rules of "do your own research" as is commonly said in this space. Also dont want a good source thats running cards to get burnt and stop taking cards would suck for yours truly. All in all I am glad people are coming around and getting great prices for their health journey without risking/waiting on grey. Especially those like me that have the patience threshold of a squirrel with an acorn.

Sincerely thank you OP'er for this thread, it helped me take the leap forward and has been one of the best decisions I've been asissted in making for my little P.I.C(Partner In Crime) fluff ball of a pomski. Thanks from JuJu and Kodah "Klowdah" Bear

@caprimichelle

I wouldn’t worry too much about a 1.6 lb gain from one shot. Weight can fluctuate from water, food, hormones, etc., and being down 22 lbs in 7 weeks is a much better indicator of your progress. I’d watch the trend over the next couple weeks before judging the new product.

Nexaph is well trusted in this community and unlabeled vials are common with how they operate, so that alone wouldn’t concern me. Like Steve said, Just make sure your COA matches what you received and you can scan th QR code provided on packaging to access testing info.

Also, 11.5mg on a 10mg vial may simply mean it tested overfilled this doesnt mean every vial is the same though, margin of error 1mg one way or the other, most of the time it will be overfilled so they dont short a vial from my understanding. You will see under though as well. A reputable source will lower price if not filled adequately.

I personally use Studz. Their pricing is fair, kits save even more, and their Discord has lots of people sharing their progress.(if interested in joining Studz discord, I can send you the link) I’m about to start my second vial and have really enjoyed the quality. My old local supplier’s reta would leave me sick for 3 days and immediately make my chest tight; I haven’t experienced either with Studz.

That’s just my personal experience, but knowing there’s testing behind what I’m using gives me a lot more confidence. As well as the community aspect which others most likely have as well. I would recommend joining as they are wells of information plus you get the back up from other members experiences as well.

Hope this helps and welcome to the fight for health!!

@bfuller I actually went a slightly different route with my dog Kodah. He’s about 20 lbs and instead of buying BPC-157 and TB-500 separately, I decided to try KLOW after seeing quite a few people online talking about using these peptides with their pets.

The KLOW I have is an 80mg blend reconstituted with 3mL, and I’ve been using 2 units 3x a week.(the pet dosage calculator I found online said 1ui) I bumped it to 2ui to assure a proper dose considering all the fluff. I went with KLOW because it already contains BPC-157 and TB-500 along with GHK-Cu and KPV, so it seemed like a more complete option rather than buying everything individually.

They also sell Wolverine, which is specifically a BPC-157/TB-500 blend, and that may be closer to what you’re already considering.

Obviously I’m just sharing what I personally decided to try with Kodah and experienced success with. The wolverine blend may be less spicy. My little dude doesnt seem to notice though.

@STATIEEIGHT This is actually incredible to read. 17 years old and going from barely wanting to walk beyond the concrete to running 7 laps just because she wants to is a pretty amazing change, especially in only 3 weeks.

I completely understand being scared giving that first pin. When they’ve been beside you that long, you’d do just about anything to give them more quality time, not simply more time.

Seeing her rediscover something she clearly enjoys has to make that decision feel worth it.

Stories like this are really interesting to follow, especially with an older dog where the change is so noticeable. Actually living out the golden years gracefully

@researchcat That’s exactly what I was curious about! I was actually diagnosed with osteoarthritis at the ripe age of 22, and I’m 36 now. Over the years, and especially since using peptides and GLP-1s, I’ve started to realize that an old injury from when I was a kid likely played a big role in setting me down this path.

Between peptides/GLP-1s, massage, and chiropractic work, I’ve been able to really focus on correcting the way I walk and carry myself, and it has worked wonders for my joints. It definitely hurt at first as my body adjusted. I ran Cartalax and KLOW during that process as well, hoping to support the connective tissues that had spent most of my life being stressed in awkward positions.

Obviously that’s just my personal experience and I can’t say which piece deserves the credit, but the difference in how my joints feel today is pretty remarkable. I’m definitely going to dig deeper into the osteoarthritis/GLP-1 research. Appreciate you pointing me in that direction!

Also, congratulations on all your success with you're healing and fitness goals. For me it's an addiction, I actually appreciate for once

@mikebricker

20 lbs in 4 months is awesome, congrats!

I’m also with you on there being benefits beyond weight loss that make me interested in what long-term maintenance might look like. I’m particularly curious to see what the research eventually tells us about Reta as more data becomes available.

And a biological age of 55 at 68?! I’d be pretty damn happy seeing that come back on my bloodwork .

Why not attempt to live longer and stronger while here for ourselves and the ones we love. Great work brother!!

@jackiee I can imagine that would be a hard position to decide from. Short of engorging yourself for several months just to justify using it, I would definitely consider the method NobleOne mentioned.

I’ve seen similar approaches throughout different forums. Maybe not exactly three times a week, but people adjusting based on how their body responds, which I think is really the best approach. I’ve seen people mention going as low as 0.5 once weekly.

Obviously, I can’t tell you where the threshold for benefit would be. With it being longer-acting and building in your system over time, I would assume a lower dose could still potentially provide some of the desired benefits as it accumulates.

Trust me, I can still eat if I truly want to I just usually end up regretting it that evening when I’m trying to sleep.