Peptide Critic Community

I'm all for keeping things in order - I've seen plenty of thread moved here.

Is there some reason why my post about my app was deleted?

The cracked vials were likely from shipping/packing conditions. They packed the plastic kit boxes in a single layer bubble wrap envelope, and put that in a box which, if one only ordered one or two kits, would have a lot of space to bang around in.

The fiber, to me, looks like something from carpet; but def not hair, at that scale.

I have 2 kits from the same batch, and 4 other kits from 2 other batches during this same order, all look as clean as any other puck I've received, and no cracked vials.

Some beat up, crumbled pucks, but that's about it.

@Logan A minute is dedication to research

I just used Stripe fine.

Inventory is locked in people's carts until they checkout or cancel, so it goes up and down like crazy.

I couldn’t find anything that did just what I wanted, so I wrote a new app.

I hope to be posting it about it on this board soon. iOS only, TestFlight beta access at first.

Makes sense. When I buy from Nexaph, it shows up as something like “C*ezp Nexa”.

I figured they sold the lower quality stuff through Nexaph, and their more guaranteed through EZP?

A peer’s mainstream source has dropped coverage, and cannot afford to continue using name brand research products. He also has Parkinson’s and can’t do the whole recon/pen fill workflows.

I just got him a kit of P2, and I told him I’d help with the workflows.

I’ve read the wonderful article on this site about empirical compound quality over time, but I’m interested in the effects on the compound when it’s in a pen cartridge, not just the original vial.

I want to fill multiple carts at a time for him, but I’m thinking I can only do 2 at a time.

Tirz was solid in the fridge for 60 days (~92% efficacy), and each cart will last 3 weeks at a 10mg /week dose.

I could try to recon 60mg in 3ml, and make it last 6 weeks per cart, but does tirz have any side effects injecting that concentrated?

@kenhnsy said in I'm Hooked On Pens:

@Splinter said in I'm Hooked On Pens:....

I don't think it is the mechanics of the pen. I posted about how bubbles which coalesce in the vial slowly keep expanding even after the push is done. Just leave the needle inside your research beast for 10 more seconds after the push.

I have found that more careful filling (metering in slowly onto the side of the vial) has greatly reduced the amount of micro bubbles you see clinging to the glass. I waste less research juice now since I do not have to purge air three times.

Thanks for the tips.

You don’t think it’s temperature expansion, coming out of the fridge?

Why would air be expanding, regardless if it coalescences into one big bubble?

Do yalls Gansulins emit a few extra small drops of compound after the needle is pulled out but still screwed in? Both of my gansulins are doing that. Going to look for a way to calibrate it maybe.

@SR04

I went looking for the same thing and jimmy rigged my own in Bambu Studio.

Can’t paste the 3mf here, but lmk if you want it.

I used that stupid plunger model (the one that introduces contaminated air on the backside of the vial), and I hollowed out the core so the vial slides in 75% with just a touch of grip at the bottom 20%.

@quicksilver80

I feel you, culture assigns all kinds of dumb names to good things.

I think I was just surprised with there being more than just glow and klow, I’m still new to the scene.

Since this post I’ve learned there are many more blend hypotheses.

@MyB

? You can choose to receive my words however you want buddy.

I’ve used lactic acids and scrubbing for KP, and I have scars to show that is not helpful for my skin.

@MyB

Physical abrasion is temporary and painful.

Pores become blocked by keratin plugs, the skin is overproducing.

If you constantly use acids to dissolve them away, you will have to keep it up daily, and you will be sensitive to sunburn way easier.

@flyhigh

I’ve been concerned / monitoring RHR in my ts, but it seems pretty stable.

Can you speak to how much of a % jump in RHR you saw while on Reta?

https://southernaminos.com/product/metaboluxe-120mg/

Thoughts?

Anyone stack these 3 alrdy?

Thoughts from 5.5 Pro

How they could theoretically help each other

1. NAD+ + 5-Amino-1MQ: “supply + conservation”

The theoretical pairing is coherent:

• NAD+ / NAD precursors aim to raise or support the NAD pool.
• 5-Amino-1MQ inhibits NNMT, an enzyme that methylates nicotinamide. Since nicotinamide can feed NAD salvage, NNMT inhibition is hypothesized to reduce nicotinamide loss and support NAD availability.

That said, this is not the same as proving better human outcomes. The strongest human NAD evidence is biomarker-based, and 5-Amino-1MQ has not been clinically validated for metabolic enhancement in humans.

2. MOTS-c + NAD+: mitochondrial stress signaling + cellular fuel economy

MOTS-c is framed as a mitochondrial stress-response peptide, while NAD biology is central to mitochondrial redox and energy metabolism. The theoretical synergy is:

• MOTS-c pushes metabolic adaptation, especially around skeletal-muscle glucose use.
• NAD+ availability may support the intracellular machinery needed for energy turnover and repair signaling.

This is mechanistically plausible but not clinically proven.

3. MOTS-c + 5-Amino-1MQ: exercise-mimetic overlap

MOTS-c is linked to exercise-induced metabolic signaling, and 5-Amino-1MQ showed additive effects with exercise in aged mice. That makes the pair theoretically interesting for:

• skeletal muscle metabolism,
• insulin sensitivity,
• exercise tolerance,
• body-composition remodeling.

But the evidence is animal-heavy. A current ClinicalTrials.gov listing describes a Phase 2a trial evaluating investigational MOTS-c versus placebo in adults with prediabetes and overweight/obesity, which means human efficacy is still being actively tested rather than established.