GLP-1 blunting neurotransmitters is a know side effect to the point that anyone with a history of transmitter imbalance was excluded from the phase three trial of Reta.
I made a post a few weeks ago about it because I was in a very dark place after a dose increase. One reply was someone man-xplaining diet and nutrition. I find it comical now but at the moment it sent me into a tailspin of rage. I dialed my dose back down and the anhedonia symptoms lessened.
Since reta causes dysesthesia and anhedonia at higher doses, I don’t know how that’ll go over with public once it’s released to the market.