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Peptide Discussion

623 Topics 7.6k Posts

General peptide discussion — compounds, goals, side effects, stacks, dosing, and beginner questions. Tag your topic with the peptide name, your goal, and thread type (2–4 tags).

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    @landonpaulovich said: My morning igf-1 levels are 350 and the ref range is 150-500 so that is fairly average. Do you think a 2 month “cycle” would be worthwhile? No. A 350 IGF-1 is still a really, really good number. In fact we see people who have very low IGF-1 scores, go on HGH or GH peptides and get numbers in the 200s and see fat loss, improved recovery, increases in
  • Nasal spray sale I came across.

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    Snake PepskinS
    I have. Not for nasal sprays, but other peps. They came in impressive packaging, I almost didn’t want to throw the case out. And had good results. Their prices are good on some things, high on others, but they do run good sales. I’ve received their stuff in two three days generally.
  • MT1 Body Composition

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    @diegoc gym is correct. That means those boners are 100%, all natural Diego boners! Congrats to you my friend. You are indeed turning back clock, while getting shredded. Props dude!
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  • GLP-1 use linked to lower breast cancer

    glp1-s glp2-t glp3-r
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    EXTROPIANE
    @STATIEEIGHT if you are relying on peps to do all the work. You'll be disappointed. Peps are tools and the tools dont move themselves. I do make great flourless sandwiches by the way. All protien baby!
  • Nasal NAD+, and/or DIHEXA

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    Snake PepskinS
    Well... they are ordered... I'll let you guys know.
  • Casomorphin and gliadorphin the bad peptides.

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    EXTROPIANE
    "Casomorphins and gliadorphins (also called gluteomorphins) are bioactive opioid peptides created when the body incompletely digests casein (from dairy) and gliadin (from gluten). Because they share a similar N-terminal amino-acid sequence, these exorphins can act directly on the nervous system, mimicking the effects of opioid drugs. If the peptides manage to breach the intestinal barrier (leaky gut) and the blood-brain barrier, they bind to opioid receptors in the brain. This activity has been hypothesized to alter focus, mood, and behavior." Basically a leaky gut makes the 'slop more addicting.
  • Tirz and reta stack???

    cagrilintide glp2-t glp3-r
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    @Shaqdiesel said: Try Epitalon / Pinealon? That helped my REM. My deep improved with Tes/Ipa. I have struggled with the same issues you have. I knock out easily but I would wake up right around 1 to 2am with a cortisol spike and then just have my mind race until I give up and just go into work since I am up already and the rest of my house is sleeping. This has improved tremendously with the 2 stack mentioned. Ok, I'll look into it. I'm in an off cycle with Tesa right now, but never added the ipa. I have cjc/ipa in transit to try. Epa and pine hasn't hit my radar yet, so I need to look more into those. Thank you.
  • DPP-4 inhibitors for your GLP/GIP?

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    EXTROPIANE
    Could this be one of the reasons most on GLP1 and GIP stall/stop working? The cause being DPP-4. All on a GLP1 should watch this video. https://youtu.be/FjIamyuWfak?is=oRGg6apu8LrHxIvj
  • Manufacturing of peptides

    beginner-question side-effects
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    @jamiegallien They give Fent. test strips away with narcan here, its almost like a ph test strip
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  • Starting Tesa/Ipa

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    EXTROPIANE
    https://youtube.com/shorts/NI8fqZ9eH64?is=ufRLCCT44QpBa3Q9
  • Is there a peptide or stack that can flow state?

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    EXTROPIANE
    "How Peptides Influence NorepinephrineNorepinephrine (noradrenaline) is a "fight-or-flight" neurotransmitter and hormone. It is synthesized in the body through a specific enzymatic chain reaction that begins with the amino acid tyrosine:(\text{Tyrosine}\xrightarrow{\text{Tyrosine\ Hydroxylase}}\text{L-DOPA}\xrightarrow{\text{DOPA\ Decarboxylase}}\text{Dopamine}\xrightarrow{\text{Dopamine\ }\beta \text{-Hydroxylase}}\text{Norepinephrine})Specific peptides alter this pathway or downstream receptor activity:Semax: A synthetic regulatory peptide known for its nootropic properties. Research suggests it can enhance and modulate levels of monoamine neurotransmitters in the brain, including norepinephrine, serotonin, and dopamine.VGF (Nerve Growth Factor Inducible): This polypeptide is naturally expressed in brain cells and endocrine tissues that synthesize and store catecholamines (like norepinephrine). VGF acts as a neuroendocrine regulator and its production is tied to synaptic health and stress response.Neuropeptide Y (NPY): This is one of the most widely distributed natural peptides in the brain and sympathetic nervous system. It is often released alongside norepinephrine and plays a critical role in managing stress, circadian rhythms, and mood."
  • CoA - Heavy Metals

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    Peter Magic, the owner of Janoshik said he has never had a peptide test positive for heavy metals. He said 100s or thousands tested.
  • Free Growth Hormone (GH).

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    EXTROPIANE
    The best stack I seen out here is CJC Ipa no dac and tesa for GH. I have a friend that is doing a protocol. His body composition is changing. His output at the gym is great but I personally don't see him gaining like test booster supplement that you can buy over the counter. I got him for the protocol and it wasn't cheap, agree. And to think with just sleep alone.
  • NAD+ Dosing Help

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    @EXTROPIAN NAD
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  • Mixing Tesamorelin with other peptides??

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    I use Tesa and Ipa mixed in the same pen. In fact a lot of places sell it (in the Vial) together already. Everyone’s beloved Nexaph sells Tesa/IPA 10/3 Blend… I
  • Epitalon protocol, is it meant to be high doses?

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    vpeptidesV
    @EXTROPIAN it's very hard to see if it is helping if your research doesn't have a target goal. You have to run all kind the tests, like metabolomics, proteomics, all -omics before and after, then compare and make a guess, what's coincidental and what's not. Also, if you mix-in another treatment at the same time it makes it magnitudes harder. And not knowing the effective dose, or changing it over time brings another layer of complexity. I will not even talk about the quality of the testing product.