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Peptide Discussion

624 Topics 7.7k Posts

General peptide discussion — compounds, goals, side effects, stacks, dosing, and beginner questions. Tag your topic with the peptide name, your goal, and thread type (2–4 tags).

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  • Researching Neuroplasticity Peptides

    researching
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    brithusB
    @EstrogenDragonLover Memory and learning results are often uniquely varied with each lab subject. A lot of different things can affect memory issues like injury, disease, nutritional deficiency and aging. For age-related memory enhancements with no other known issues, I personally would start by checking labs on vitamin levels for vitamins D, K, B12, B6, Folate & iron/ferritin. Deficiency in these can significantly speed up age-related cognitive decline, and reduce brain fog, learning, focus, and memory abilities. Research studies show that nearly half of people with aging memory/learning problems are deficient in many of these nutrients. Another supplement that is useful but you cant really test is DHA/EPA (omega 3). Make sure you use a quality supplement brand though or you will be wasting your time and money. If you dont have nutritional deficiencies or injury/disease related and just want to enhance learning and memory abilities, I would start with prptides that increase BDNF and synaptic plasticity. The ones I have personally found most helpful are Pinealon, Semax (or a Selank/Semax combo was better in my opinion), and NAD+. Dihexa and P21 are also good but nearly impossible to find lately. If your issues are from aging then you may want to also look into peptides that deal with cell renewal, neuroinflammation and mitochondrial repair. I have found BPC-157, TB500, KPV, SS-31, Epitalon, FOXO4-DRI, and Ipamorelin to be most beneficial for me. Hope this helps.
  • Pinning a Rats Shoulder, Back and Knee

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    @neil-mccauley made some great suggestions. You might also look at SS-31/MOTS-C to rejuvenate your energy. I have been researching Wolverine through S-KLOW/Klowverine for almost a year with few breaks and it has been a huge help both physically and mentally. (Klowverine is Wolverine + Klow in one vial/cart, basically double the BPC/TB500). My knees and shoulders are better than in many years. I am experimenting with the idea that older cats can and should research higher doses of Klow and its constituent peptides.
  • AI analysis and tier list of peptide vendors?

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    BoxerLoverB
    Speaking of peptide vendor analysis, has anyone heard of https://titratelab.com? I saw this posted in another forum I belong to.
  • 147lbs @ 8-10% BF – Worth Adding Tesamorelin for the Final Push?

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    @Neil-McCauley Got it. Let 'er rip!
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    @davidwaisanen1 I run it at 3 to 4mg daily
  • Zepbound

    glp2-t researching
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    mrjoshua44M
    @TheHazmatGuy I'm not disagreeing with you however, if you are buying on the grey market how much are you spending for third party testing? Or lab work? Sure, I've purchased backup vials of both Tirzepatide and Reta, and have purchased many kits from Nexaph. But like I said in my post, I like having the ability to message my Telehealth provider and Nutritionist whenever I have a question or concern. I'm doing things by the book as much as I can. I value the relationship I have with my PCP. I'm not going to go out Doc shopping just to find one that doesn't care what I put in my body.
  • 2 months on Reta update

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    vpeptidesV
    @danny2 said: There's only one fastest way to lose weight. It's to stop putting food in your mouth and swallowing. That's it. That's my mantra. But I usually add: eat less and poop more.
  • Pinning TB500/BPC for elbow

    bpc-157 wolverine
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    MyBM
    @theone here is Randy’s protocol for BPC-157 https://community.peptidecritic.com/post/373
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    vpeptidesV
    You may take a blood test for IGF-1 to see how your current protocol affects you. Usually 120 to 200 ng/mL is the normal range with about 160 to be optimal. Your base line may be 120-130, you would need to measure it outside of your research cycles. If you get it a lot over 200 it may be too much and have side effects for your health, probably something in the range of around 200 is OK for the protocol temporarily.
  • Efficacy of nasal vs. subQ for neuro peptides

    Moved pe-22-28 researching pinealon dsip
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    @gym.rat Dang that sucks. I guess that is why we all must do our own research. Everyone gets a different outcome and degrees of outcome.
  • Tesamorelin/Ipamorelin and Huperzine A for somatostatin inhibition

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    Is anyone here using Huperzine A with Tesamorelin/Ipamorelin (or other growth hormone secretagogues?) Theoretically Huperzine A inhibits acetylcholinesterase (AChE) which is the the enzyme that breaks down acetylcholine. That leads to higher acetylcholine levels. Higher acetylcholine levels in the hypothalamus are thought to stimulate the cholinergic pathways that suppress somatostatin release. Somatostatin is the body's primary inhibitory hormone; its job is to put the brakes on natural growth hormone release. So in theory, taking 100-200 mcg of Huperzine A taken 30 minutes before administering your growth hormone secretagogues should lead to a stronger cleaner growth hormone pulse. Curious if anyone has experience (or more data) on that?
  • Testing for TFA and excipients

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    Just FYI for those that may want to listen- Dave Asprey. YouTube. June 2. Interview with Justin Kirkland. Starts at min 17 when they discuss the process of modern (solid phase) manufacturing of peptides. Kinda cool to hear what happens behind the curtain. Haven't gone down this rabbit hole yet. Anybody else?
  • A few very basic Pen questions

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    I would do the Tesamorelin and Ipamorelin (that is what I do) As far as pens go, get good quality, not Amazon, Etsy, eBay, etc.. crap. I would definitely get at least 1 auto pen (lGansulin/Convi), they work great for hard to reach places (like sub-q in glutes) and a high quality manual pen. Novo, xulin, or a real v1 (if you can find one). Novo are the hardest when you are new, it doesn’t work straight out of the box… You will need at least 1 pen for every peptide you are going to take…
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    vpeptidesV
    I have heard from a practicing MD - peptide researcher that mixing random peptides together as a blend is not ideal and better to be avoided. The reason is that different molecules may demonstrate unwanted interactions with each other, we just don't know enough of chemistry and don't have a research of how they will interact. For example they may stick to each other, block each other, even react chemically. He suggested to use different vials and syringes for each peptide and even spread them in time enough to avoid interaction with each other in the body, unless it is the intended effect that you want. That's what he does with his clients and he has a large clinical practice.
  • Cagri recon and safety questions

    cagrilintide reconstitution storage
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    NewenoughN
    Disregard. I misunderstood. When you say tossed after four weeks, I assumed you meant the remaining BAC water, as you'd not be using it quick enough. I reread it again, and see you probably meant the cagri.
  • Janoshik COA site not working?

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    M
    @Eleanor I wish I would have checked all my QR codes right when I got them! Now how do I know how much Nexaph overfilled?
  • ILS Labs

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    Does anyone have experience with this lab? If I understood the pricing correctly, it is $150 for Purity & Mass. But not 100% sure I am correct on that…
  • Dsip purity test

    dsip
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    WisGal64W
    The purity came back the 3rd party results are 97.949%, 98.032% and 97.999%
  • TA-1 Cloudy

    Moved researching thymosin-alpha-1
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    vpeptidesV
    Ok, I asked the Omniscience AI and it stated the obvious: Cloudiness indicates that the TA-1 molecules clumped together instead of dissolving. When you reconstituted the freezing cold powder, a significant portion of the Thymosin Alpha-1 molecules collapsed and clumped together (precipitated) because cold temperatures decrease peptide solubility. Because these clumps were large enough to scatter light, the 0.22-micron filter likely trapped and removed those un-dissolved clumps. Because an unpredictable amount of the peptide clumps was filtered out, your final solution is likely under-dosed. You cannot accurately know how many milligrams of TA-1 are left per milliliter. Because the solution was originally cloudy from being mixed while cold, the exact composition of your clear 5 mg/mL solution (10 mg in 2 mL BAC water) remains highly unpredictable.
  • Two interesting articles on Survodutide recently published

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    E
    Yeah, but here's another article published yesterday. Seems someone(s) want to possibly get rid of Survo: https://www.cnbc.com/2026/06/08/weight-loss-drug-stock-zealand-pharma-data-ada.html