Peptide Critic Community

I ain't upset that Nexaph overfills its vials a tad

Rumble is awesome and I've been on there for awhile now. I ended up on there when a lot of my favorite political commentators got booted off YT.

Maybe, maybe not. I panic bought a horde of bac water a month ago at what is now an absolute steal, and I'm certainly not regretting that purchase.

I stocked up on a bunch of kits as well. I think if it's something you know you're going to use, you've been using it for awhile with good results, and you've got the resources, I'd stock up a little.

@EXTROPIAN said:

@jimmy4407th Dial tesa down and be patient. The stuff is is strong even at 1mg. Well for me it is. Water retention, inflammation, tingling... That's you body telling you to chill.
Your body has your best interest. It is constantly keeping you alive regardless what you do to it. Be patient and listen to it.

Similar experiences. 1mg is plenty if your pituitary is functional. Especially if you're running Ipamorelin (which you should be) alongside it.

My experience with Nexaph was excellent too. Easy to order, website smooth, credit card, free shipping on large orders, shipped fast, responsive customer service inquiry, etc. It was so smooth in fact that it was too easy, in that Nexaph is probably going to end up too successful and get too much attention and get shut down eventually. Which means if you're in need of anything, I'd stock up now while they're still in business.

If there is one positive of the sites that have hoops to jump, middle men, discord and telegram groups and crypto, is that it's too much work for the normies and will fly under the radar. Nexaph seems too good for it's own good in a way, if that makes sense.

What were your IGF-1 lab markers at? Swollen ankles is a very common side effect of excessively high GH levels. Any tingling feelings in the hands?

What's your blood pressure? What dosage of Sermorelin are you using?

31g EZ touch from Amazon. They're good for 5 years so I stocked up and you should too, I've got a hunch that they too are going to start disappearing.

Sure, there will be places to procure them online, but not at the current prices.

@jborja said in Tesamorelin Research Dosing Protocol:

Hey friends, @randy might have opined on this also, but curious to hear what others think. I saw another video that nightly tesamorelin might be impacted for those taking Tirz or Reta due to slowed gastric emptying, meaning that folks are not as truly fasted and still carrying heavier insulin when they poke before bed.
I like Tesamorelin/ipa at nights due to restful and deeper sleep (even with toddlers), but I am on tirz and try to have my last bite 3 hours before bed. Not sure if eating dinner 4 hrs before is doable..
Curious to hear your thoughts about a morning routine instead? For you morning folks, do you just wait at least 30 mins before a pre workout? I was gonna try Tesa at night and Cjc in the morning but might be reconsidering this to not have duplicative secretagogues at the same time. Ty!

I only research my GHRH/GHRP peptides in the a.m., first thing fasted now, for a whole bunch of reasons. It's just easier and more convenient for me, I know I'm totally fasted with insulin at its lowest point (and therefore getting the strongest amount of receptor saturation as possible).

Plus I'm just more awake/alert in the a.m., easier to pin and reconstitute if need be. I spent many late nights in years past pinning/researching before bed after a long day and when tired, it's just difficult.

I wait 2 hours before eating anything. I drink black coffee right away in the morning after pinning and the combo of peptides, coffee and being fasted in the a.m. is a superpower for getting stuff done. Plus I find GH peptides stimulating in a way in the morning.

I like the idea of going natural at night (no GH peps) and really letting my natural production do its thing. I have found that there must be some carry over anyways, because on cycle my rat sleeps better even though he pins in the a.m only.

Rather than trying to find a way to squeeze in Tesa/CJC in the same day, I'd recommend you use one or the other during your cycle. You can flip flop them as well, going back and forth when one vial runs out.

Also don't forget, every time that needle penetrates something, it gets dulled and loses lubricant as well. Bad enough you're using it once to go through a rubber stopper - even worse you're doing that a second time. Hence why peptides that can be injected together, like CJC & IPA, are usually combined prior into one vial.

You can also use Google Scholar. Many of these peptides have clinical research and data with study participants. I'd suggest reading the data, often very descriptive protocols are given including dosage information.

@Commander said:

I won’t use a reconstituted vial for more thsn 5 weeks.
Look around here, you will find articles on degradation of peptides after they have been reconstituted. They start to loose they potency….

https://peptidecritic.com/blog/peptide-degradation-and-storage-tirzepatide-mots-c-and-mazdutide-lab-results

Tirz only dropped from 94% to 92% from day 15 to day 60.

Bac water tested plenty safe at 90 days, and even then its a slow degradation afterwards.

My peptide research is limited to the GHRH/GHRP compounds fwiw. My experience researching them is extensive.

In my lab, I am maintaining a 60ish day window before discarding. I think that's fairly conservative and staying on the safer side without being wasteful and unnecessarily paranoid.

@Commander said:

@Randy
When on HGH or Tesa, what is a target igf level for max effectiveness? I know it is somewhat age dependent, but what level would be optimal for say some 40 and then someone 50?

Conservative sweet spot to maintain anti-aging while also balancing side effect concerns/cancer would be 180 - 220. At that range you're going to get all the benefits including improved sleep quality, tissue repair, healing, immune system function, while also minimizing risks. This range is applicable for all adults really. It would be a little in the low end for a growing adolescent, but for a full grown adult of all ages this is the level you're looking for.

If you're above that naturally good for you, I wouldn't worry about it unless it's way beyond the top range and you're experiencing side effects.

You're not going to see drastic changes in muscle mass/fat loss at that level, you're going to need to do the work to get that, but you're also going to put the side effect/cancer risk at that level to extremely minimal.

The real drastic changes you see with people on GH in terms of size come with levels in the 400 - 500 range. Personally I would not be comfortable long term pushing levels that high, the risk/reward ratio IMO is just not worth it.

@hunt_ak said:

Just finished a test vial of Tesa after running CJC/IPA for 12 weeks. Had 10mg from a friend so decided to run 5 day course of the vial. No flushing like CJC (as mentioned above), but after 3rd day, joints started to hurt a bit and scale up 3-4 pounds from water retention. Wasn't a fan...CJC it is for me.....well....GH, really...

If you're headed somewhere, just go there...

2mg is way too high of a newbie starter dose. You should have gone 1mg. Also, the water retention and joint issues is a by product of high GH......which means it was working.

If you're so susceptible of side effects from GH that 2mg of Tesa gave you joint pain and water retention within the first week, even something as small as 1iu of HGH is likely going to do the same thing.

What is your baseline igf-1 level that you're going from?

@coondogesq said:

@ResearchCat My dumb question of the morning. Since I typically don't eat in the morning either, I'm leaning towards morning doses when I start my cycle. With that said, i do usually have a protein drink and fiber drink in the morning. While not eating per se, should I delay them for a couple of hours if I decide on the morning protocol? I suspect so, but don't want to overthink it. Thanks for any imput.

Go the full 2 hours if you can. The GH boost is primarily within the first 60 minutes post pin, but there is a transient amount in that second hour that ideally you want to take advantage of.

@hunt_ak said:

@Stevepep as far as I understood the GHRH analogs (CJC/IPA like you mention) are going to pulse GH, telling your liver to produce IGF-1. An increase in IGF-1 production shouldn't have a correlation to testosterone production.

Am I missing something here? Seems to be two different conversations.

They are bigtime correlated. People who use GHRT often see, on average, a 10% increase in testosterone levels, although some see increases much, much higher. Same goes in reverse - those who use TRT often see an increase in that same 10% or so range in IGF-1 numbers.

This is also true of DHEA replacement - it will often move the needle for both IGF-1 and testosterone. All these hormones seem to work in concert and there is overlapping everywhere.

When things go decline, hormonaly speaking, they tend to drop everywhere. When one hormonal level breaks and degrades it tends to drag others down with it.

The good news is that also works in reverse, when you fix one aspect of the hormonal symphony, others tend to get up to speed and repair themselves, at least to some partial degree.

Let's use GH for example. As GH levels and therefore igf-1 levels decline, we see both Increases in SHBG levels and a decline of LH function in the testes. Both of these in turn also contribute to lower testosterone levels.

Increases in igf-1-->lowers SHBG levels back to normal baseline. It also reinvigorates the leydig cells to work again and respond to LH signaling. Bundle those two together and you see increases in testosterone.

Testosterone is partially responsible for the GHRH pulses in the HTPA. So as your Testosterone levels decline in age, so your GH pulses in the pituitary. Take an exogenous drug like testosterone that amplifies GHRH pulses and you see increases in igf-1/GH levels. We know this from studying puberty - the dramatic shift in increasing igf-1 levels are partially androgen driven, not necessarily from any changes in the HTPA elsewhere.

Testosterone also has a positive effect on GH/igf-1 receptor effectivess throughout the body, not just the liver but also all the tissues as well.

@vpeptides said:

You may play with lowering Ipamorelin dose. 0.1 mg is known to saturate the receptor for the most.

If you're a newbie I am leaning towards 2mcg/kg to being the best saturation dosage while not being wasteful/diminishing returns/over saturation of receptors. It's not that much more as it really ends up being around 150mcg for most but I think that little extra seems worth it, at least in my experience.

You definitely don't need those huge 300mcg twice a day dosages unless you're really experienced in this.

Same with Tesa. If you're new to using it, definitely start with the 1mg dose. I prefer the 10mg/3mg blend that has Ipamorelin. It's often added with a minimal cost and it adds a nice multiplier to the Tesa, and gives you that 150mcg dose noted above.

@ManicXmedic said:

I believe the issue is blood sugars, when they're elevated it contributes to somatostatin which is the growth hormone blocking hormone. Some people will fast and still have high blood sugars from having some insulin resistance, which imo needs to be addressed so that we're not getting water retention and carpal tunnel sides without the benefits.

With reta if you're still digesting dinner after 2 hours your blood sugars will still be elevated.

I'm currently working on getting my fasting blood sugars routinely 90 or under before I start gh or gh releasers. for what it's worth I'm still trying to figure alot of peptide information out and I may be off base but hopefully it adds to the discussion

Your body, in an evolutionary adaptation, knows that if you've eaten food, you don't need GH to break down stored fat, so it shuts down the whole GH assembly line.

I wouldn't wait to get your fasted glucose under 90 to start GH boosters, especially if you're over 40. Often these drugs in of themselves can actually improve insulin sensitivity over time via improved lypolisis. Definitely try the secretagogue path first to see how well you respond.

@Ctrain24 said in Bacteriostatic water source:

@Juan-Doe said in Bacteriostatic water source:

@Randy Awww geez. for crying out loud!
So I cant just purchase a case and keep it in my closet for the rest of the year?
Dang it.

The results Randy posted are once its been used. Unopened BAC water has an expiration date on it . My recently purchased Hospira bottles have a Sept. 2027 expiration date

And that's Hospira being extra cautious/covering their butt about their product......if it was recently purchased and stored in a cool, dry place away from excess heat/moisture, I'd trust that water anytime in 2028 as well.

@Eleanor said:

@WisGal64 I have 2 sm vials of Tesa and terrified to try it. Already have edema, tachycardia and joint pain. I'm GUESSING that if one already has these sx's, even subclinically, Tesa will rocket them to the moon. Danged shame...

You can try running Ipamorelin solo at 100mcg. It will still provide a GH/IGF-1 boost albeit at a much more conservative amount, and you would likely avoid those side effects.