A few weeks ago I had a discussion with my doctor, who has been running a clinic that specializes in stem cells, down in Tijuana. I noticed that they are also using Peptides to help their patients with any chronic pain, inflammation, and all around health. I asked if he could take a look at what I had been researching with. At the time I was researching with 4mg Reta, 300mg AOD-9604, 1mg GHK-Cu, 425/250mcg ipa/cjc no dac. I brought up that after being on Reta for 6 months that I ran into a stall and he suggested titrating down to a 2mg for 2 full months to help reset the receptors and then to slowly titrate back up. It’s helped his other patients out to continue loosing weight. I’m currently on week 4 of 2mg. Has anyone else tried this after a stall or similar ? What were results? Have you tried stacking anything else. I’m currently down to aprox 260 lbs and down from 335 lbs. I’m also thinking about introducing Cagri into the stack as I have a binge issue. I have been hydrating with min 220oz water daily, protein/fat/carb ~200g/~80g/~120g, ~ 7.5 sleep daily, 2 days resistance exercise, 3 days of 7.5k steps & 3 days active around house.
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Has anyone ever ordered from AmericanPeptides.us?
I did a little online research and they seem legit. Just wondering if anyone has used them and is willing to share their experience.
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Watch on RandyTube: How to Get Started With Peptides: The Supplies You Actually Need (Video)A beginner guide to the basic supplies a new peptide researcher actually needs: the simple setup for reconstitution, measuring, clean handling, storage, vials and cartridges, plus optional pen systems, and which popular "must-haves" are mostly unnecessary.
Comments posted here show up under the video on PeptideCritic.com, and vice versa. Questions about the technique, gear or the math are all welcome.
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Discussion thread for the blog post on PeptideCritic.com.
Read the article: Accumark - The Lab Selling Transparency Forgot to Explain Who They Are
Share your thoughts, ask questions, or continue the conversation below!
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The Main Site and the community now both have Dark Mode, if you have dark mode enabled on our browser or computer it should automatically detected it or you can toggle it with the Sun and Moon buttons:
Right now we are using the Superhero Skin for Dark mode in the Community you can also change your skins in the main menu.
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I’m in the Amazon review program called V I N E. (Had to put spaces because it’s against TOS to tell anyone publicly). I often see things when they are new and discounted to encourage sales. Anyway, I thought I’d make this topic to post my finds instead of putting them in the swag topic I usually do.
These insulated storage containers are $9.99. Usually they run $15-$20.
amazon.com/dp/B0H11KL7M3
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I suppose a progress report/results post is long overdue. I don’t like sharing too much specific, but here we go.
Subject: 58 year old male, family history of hyperlipidemia and heart disease.
Start Date: 12 Aug 2025
Weight: 200 lbs
Height: 5’8”
Note: Subject lifts weights regularly, does jiu jitsu 3x a week, walks 45m/day. Has chronic shoulder injuries and knee pain. Various other issues. Trouble losing weight.End Date: 28 Aug 2026
Weight: 166.8 lbs
Note: Shoulder pain mostly gone, no knee pain. Subject lifts weights 4-5x/week, has hit numerous lifetime PR’s, still does jiu jitsu, walks daily and sometimes runs.Current Protocols: Tirzepatide, 6 mg weekly
Protocols during report time: Epitalon, Sermorelin, SS-31, MOTS-C, NAD+, CJC/Ipa, Tesa, Wolverine, Glow, Klow, and probably forgetting something.
Also, lots of supplements, and added Rosuvastatin and Repatha for high LDL and LP(a)
Measurements:
Progress pics: Before/After
These scales rely entirely on electrical conductivity, hydration is the single biggest variable. Weighing in right after a heavy workout (when you're dehydrated) or after drinking a lot of water will temporarily skew the resistance. I take my measurements first thing in the morning before eating, drinking, or training. Also a 4 electrode is not nearly as accurate as an 8. The 4 is estimating your upper mass with an algorithm. The 8 sends the current through your whole body. I love these scales for trends but would not use it for anything that requires an accurate number. -
Given the video I posted in this section about Mitochondria, I rearranged my pep starting schedule to start SS-31 tonight. As someone who had advanced Lyme Disease, it's known that my mitos are not in good shape and I'm not fond of previous 'suggestions', esp. from physicians.
Rat hit 500mcg in the hip about 1.5 hours ago and I'm trying to track what changes, if any, might occur. Taking NAD+ buf 20mg. (cut back from regular dose) just as support. No MOTS-C yet; not for some time. No Cartalax reload, which makes me nervous but will have to see how it goes.
If you're someone who's just started SS-31 FOR THE FIRST TIME, please let us know your experiences. Let's hope we see some great results.
This thread to be continued until whenever...
read more →@damic pinned 1-3 the first week then onto 5 the second and third week the. Fourth moved to 9-11ish. Then stayed for a week or so. Then moved up towards 20 over the course of a week and just stayed there for another two weeks. I stopped last week for no particular reason and it’s seems like I’m maintaining pretty well. Not as physically active this last week tho. I’ll Prolly stay off it for a while or maybe hit a 15-20 if I feel like it would benefit me that day. Same for motsc. Only as needed for time being. -
Hi @PeptideCritic team, Kobi from Popular Peptides (popularpeptides.ca) here.
Our vendor profile has a Community Alert from Sep 8 saying our COAs show the names of other companies. We've answered it publicly in our vendor thread: https://community.peptidecritic.com/topic/2983/discussion-popular-peptides-popularpeptides.ca/3
In short: we source wholesale from established distributors, and each of them has its own independent third-party testing done, so the COAs are issued in their names. We've also updated our vendor profile with an accurate location (Vancouver, BC, Canada) and a description.
Could you take a look and decide whether the alert should stay as is, be updated, or link to our response? We're happy to send any COA you'd like to review. You can reach us at [email protected].
Thanks!
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This is the official discussion thread for a vendor on PeptideCritic.com.
View the vendor profile: Popular Peptides (popularpeptides.ca)
Share your experiences with this vendor, ask questions, or add information that might help other community members.
Please keep discussions respectful and factual.
@popularpeptides said: Hi Randy, thanks for flagging this. It's a fair question. Kobi here from Popular Peptides. We don't manufacture. We source wholesale from several established distributors, and each of them has its own independent third-party testing done on its batches. Those COAs are issued in the name of the distributor that submitted the sample, which is why you're seeing their company names and not ours. We'll send the full COA for any product on request. Email [email protected] or message us through the chat on the site. You can also look up batches at popularpeptides.ca/verify. Happy to answer anything else here. lol -
Hi! I’m fairly new to peptides but I’m trying to learn as I go. A number of people in my area had been recommending a Reta, Tesa, Mots-c stack as the way to go for losing weight. I finally decided to jump in and bought from Backroad aminos (recommended by all the same people). I started researching what I could google and came across this group and it’s where I think I have learned more than anywhere else. I also got some KLOW from longevity pros early on.
Currently my rat is on week 4 of Reta and it works wonders for the food noise. A week on KLOW at this point and hoping to see some benefits toward recovery from a recent surgery. My rat will be starting Tesa in another week then the MOTS a few weeks later.
I’m using “MyPeptideApp” to keep track of protocols and log shots.
I’m looking forward to good progress and continued learning!
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Thinking of adding testosterone to my current protocol, any recommendations would be great. Looking for a good vendor for it as well.
read more →@HockeyRat said: should be fairly easy to get. Understatement of the week! I am trying to think of an appropriate joke to underscore how trivially easy it is to get a script for T these days. Between the telehealth co’s and any urologist’s office, it’s so easy. Just be aware that if your PSA is high, you might get railroaded into an MRI before anyone will write you for T. -
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This is the official discussion thread for a vendor on PeptideCritic.com.
View the vendor profile: Costides
Share your experiences with this vendor, ask questions, or add information that might help other community members.
Please keep discussions respectful and factual.
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This is a vendor review submitted by Neters on PeptideCritic.com.
Rating:
(5/5) · Peptide: GLP2-T · Reviewed September 27, 2026
I’ve been ordering from Nexaph since April 2026. Comes in 10 packs I order NXP-2P 30mg 10-vials (tirzepatide) always pre-order it’s fresh batch, it’s cheaper to buy that way usually 188.00 or onsite…
Read the full review on Nexaph's page
Discuss this review, share your own experiences, or ask questions about the vendor.
Please keep discussions respectful and factual.
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This one is worth a read. A new 2026 Nature Metabolism study looked specifically at cagrilintide + retatrutide and found some interesting synergy beyond what you might expect from simply stacking appetite suppression.
Study setup:
Obese male rats were given Cagri, Reta, or the combination. The researchers also compared Cagri + Reta against Cagri + semaglutide and Cagri + tirzepatide.Core protocol:
• Cagri: 5 nmol/kg/day
• Reta: 5 nmol/kg/day
• Subcutaneous administration
• Approximately 2 weeks depending on the experiment
• Additional dose-response testing from 0.3–30 nmol/kgResults:
Cagri + Reta produced greater reductions in body weight and food intake than either compound alone at matched molar doses.But the pair-fed experiment is what really caught my attention.
Researchers included animals restricted to the same food intake as the Cagri + Reta group, along with calorie-restricted animals used to separate the effects of reduced intake and weight loss from the pharmacology itself.
The combination still produced metabolic and molecular changes that weren't completely explained by eating less.
That's interesting because Cagri often gets viewed simply as an additional appetite suppressant alongside Reta.
Mechanistically, you're combining:
Reta → GLP-1 + GIP + glucagon receptor activity
Cagri → amylin-receptor activityTogether, researchers observed changes involving central energy-balance pathways and peripheral bioenergetic/metabolic pathways, along with improvements in markers including insulin, triglycerides and total cholesterol.
The study also found the Cagri + Reta combination produced stronger weight-loss effects than the Cagri + semaglutide and Cagri + tirzepatide combinations tested.
Big takeaway for me:
Cagri + Reta may be considerably more interesting than simply “Reta with extra appetite suppression.” The pair-fed data suggest complementary metabolic effects that extend beyond calorie reduction alone.Study: Cagrilintide and retatrutide combination therapy enhances weight loss and metabolic outcomes in obese male rats — Nature Metabolism, 2026.
That pair-fed experiment is the part I'd really like to hear everyone's thoughts on. As well as the possibility of using it alongside reta to achieve results quicker and with more price efficiency.
had ChatGPT summarize this.
Why I had chat summarize: #1 being time of course... as well as having just purchased Cag to stack in with reta. In my endeavours I experienced a run in with a fellow researcher claiming adding cag and lowering reta was a profoundly stupid idea. 2 days later this study is dropped and proves that it may indeed be worth researching as it has not only showed greater results when combined it also will help to limit my expenditures on Reta.
@randallchampion There was a poll in a Discord group with a 5mg/5mg Reta/Cag blend listed, so I can only assume it was a potential new offering from their vendor. There’s definitely a group of people who believe in microdosing Reta, with some starting around 0.5mg. With a 1:1 blend, even 250mcg of each would be an interesting place conceptually. And Cag has been studied at doses into the multi-milligram range, so there may be more practicality to the ratio than it initially appears. I personally wouldn’t push Cag anywhere near the upper end, but there may be something to this combination under the surface that we just don’t understand yet. I’m interested to see where the research eventually takes it. If it catches on that is.
