Skip to content

Peptide Discussion

General peptide discussion — compounds, goals, side effects, stacks, dosing, and beginner questions. Tag your topic with the peptide name, your goal, and thread type (2–4 tags).

This category can be followed from the open social web via the handle [email protected]

98 Topics 815 Posts
Monthly Contest

No contest currently running. Check back soon!

  • Starting with healing and recovery

    Moved mots-c researching wolverine thymosin-alpha-1
    11
    0 Votes
    11 Posts
    388 Views
    B
    Copper went in with no pain today I reconstituted a 100mg with 9ml of bac water and filled 3 pen cartridges that I also filtered. The videos really help and after a month of researching, I see how you can get hooked on feeling better. If it wasn’t for the pens, I wouldn’t be researching. Thanks Randy! I just received my Gansulin Pen
  • Verified Peptides

    Moved tesamorelin researching
    1
    0 Votes
    1 Posts
    74 Views
    T
    I bought 3 vials of 20mg Tesamorelin from Verified Peptides. After they arrived I placed them in the fridge to reconstitute. On the day of I reconstituted the vial with 2mL of Bac water for use that evening. When I retrieved the vial from fridge it had completely gelled. The only other time this happened was with AOD which there are recommendations out there to use Acidic Acid to reconstitute AOD. I did see Jeff and Randy’s video on this topic. But this has never happened with Tesa. Thinking the batch is bad and not sure I want to try the other 2 vials.
  • 1 Votes
    3 Posts
    97 Views
    D
    I think Elon would love GLPs in Mars… keep ppl lean and only eating the necessary foods
  • Any one try Wolverine 2.0?

    Moved cartalax researching wolverine
    2
    2 Votes
    2 Posts
    195 Views
    D
    So couple of factors, Price and are you willing the 3 shots separately. I use all 3 separately however im shifting to KLOW and adding the Cartalax and up dose on TB 2x a week
  • DSIP (Delta Sleep-Inducing Peptide) Research Dosing Protocol

    Moved researching dsip
    7
    1 Votes
    7 Posts
    250 Views
    B
    @Randy said in DSIP (Delta Sleep-Inducing Peptide) Research Dosing Protocol: funny ive got a needle in a hospira about to recon two bottles of dsip for a pen. Ive found it helps me stay asleep not necessarily puts me to sleep. Milage may vary on timing but i usually do an hour before i am planning on zonking out. I think your plan is sound. A little info that may be helpful. I accidently grabbed the wrong pen thinking it was AOD at 7am. pinned 3mg of dsip instead. I was lucid and out of it all day. Couldnt stay awake. Anyways...it works. I will aim to take it at least 1 hour before bed .. btw thank you for confirming that this really works, i will make sure to dont ever take it in the morning now.. hahahahaha
  • Labs/Analytics

    Moved glow researching
    2
    0 Votes
    2 Posts
    86 Views
    RandyR
    we are going to be adding a section on our site with a few labs we've used. I get my IGF and other fun things with https://www.ultalabtests.com/partners/peptidecritic You can build out your own panels just by adding them to the cart.
  • Oxytocin

    Moved researching oxytocin
    3
    0 Votes
    3 Posts
    193 Views
    D
    Yes i think 2 sprays is a good start and 3 if the concert or special event is with a partner;)
  • 2 Votes
    5 Posts
    196 Views
    D
    I loaded up stock for the winter season however this peptide that is very versatile for trips and just weekly maintenance maybe 1-2x a week just to have a strong immune system.
  • Vendor Experience

    Moved researching
    2
    0 Votes
    2 Posts
    103 Views
    W
    Ive seen evolve but they are testing one bottle and its usually an overfill. That screams chinese supplier. Not a bad thing but just something to be aware of. For single bottles i like Mile High Compounds, EZpeptides and Ameano peptides. Like others on here have mentioned Nexaph has kits and I LOVE their stuff.
  • 0 Votes
    1 Posts
    78 Views
    P
    Discussion thread for the blog post on PeptideCritic.com. Read the article: PeptideSciences Removes GLP-1 Peptides as Industry Crackdown Concerns Escalate Share your thoughts, ask questions, or continue the conversation below!
  • BPC-157 Subcutaneous Research Dosing Protocol

    Moved tb-500 bpc-157 ghk-cu researching
    1
    0 Votes
    1 Posts
    230 Views
    RandyR
    For research use only. Not medical advice. Overview BPC-157 is a synthetic 15–amino-acid peptide studied for potential effects on tissue repair, inflammation modulation, and gastrointestinal protection. Human clinical evidence is still limited, so researchers rely on conservative dosing patterns derived from preclinical data. Subcutaneous administration is the most common route in systemic research models. Daily Dosing Protocol (Subcutaneous) Standard Daily Range 200–600 mcg once daily Escalate gradually to assess individual response and tolerance. Titration Schedule Weeks 1–2 200 mcg daily Useful as a gentle introduction, particularly when monitoring sensitivity. Weeks 3–4 400 mcg daily Represents the common working dose for generalized healing or recovery-focused protocols. Weeks 5–8+ 600 mcg daily Higher end of typical daily research use; often maintained for prolonged tissue-repair goals. Timing Once daily, at any consistent time. Some researchers prefer morning fasted dosing; others use evening to complement recovery protocols — timing is flexible. Cycle Length Standard BPC-157 research cycles: 4–8 weeks, depending on the model Optional 2–4 week break before repeating Shorter cycles may be used for acute-injury research models Chronic continuous use is less common due to limited long-term human data. Common Research Notes BPC-157 is generally well tolerated, though individual sensitivity varies. Some subjects report improvements in soft-tissue recovery, joint comfort, or GI stability within 1–3 weeks. Effects may plateau after several weeks, which is why cycles often cap at 8 weeks. Some researchers combine BPC-157 with TB-500 or GHK-Cu for injury-specific protocols.
  • Mazdutide Weekly Research Dosing Protocol

    Moved mazdutide survodutide researching
    1
    0 Votes
    1 Posts
    63 Views
    RandyR
    For research use only. Not medical advice. Overview Mazdutide (LY3437943) is a dual GLP-1/glucagon agonist similar to survodutide but generally smoother and more tolerable, with a softer glucagon hit and less aggressive appetite suppression. Typical weekly exploration ranges from 2–10 mg, with gradual escalation over 8–12 weeks. It has good synergy with GLP-1/GIP agonists (e.g., tirzepatide) and is commonly used in “Ghetto Reta” stacks due to its cleaner side-effect profile. Weekly Titration Schedule Weeks 1–2: Intro Phase Dose: 2 mg once weekly Purpose: Establish baseline tolerability and assess GI sensitivity. Notes: This is a gentle entry point compared to survodutide’s 0.6 mg start. Weeks 3–4: Light Phase Dose: 4 mg once weekly Produces noticeable appetite reduction but usually without overwhelming gastric slowing. Hold at 2 mg longer if nausea persists. Weeks 5–6: Moderate Phase Dose: 6 mg once weekly This is the working dose for many research subjects. Represents a good balance of efficacy and tolerability. Weeks 7–8: Strong Phase Dose: 8 mg once weekly Strong metabolic effects emerge here. Suitable for subjects who tolerated 6 mg without significant GI burden. Weeks 9–12: Upper-Tier Phase Dose: 10 mg once weekly This is the practical “top end” for most research setups. Only escalate to 10 mg after several weeks of stability at 8 mg. Maintenance Dosing (Week 13+) Standard Maintenance 6–8 mg once weekly Best balance for long-term tolerability. High-End Maintenance 10 mg once weekly Used when the goal is more aggressive metabolic impact or retatrutide-like synergy in stacks. Frequency & Timing Once weekly, same day each week. Delayed GI effects can occur (Day 2–3), especially at ≥6 mg. When stacking with tirzepatide, escalations should be slower than this standalone schedule. Cycle Length Titration requires 8–12 weeks depending on sensitivity. Full research cycles often run 16–48 weeks, typically maintaining 6–10 mg. Common Research Notes Mazdutide is smoother and less nausea-inducing compared to survodutide. Appetite suppression is strong but less abrupt subjects often describe it as “cleaner” or “more natural.” When stacked with tirzepatide, GI effects compound; many researchers cap mazdutide at 4–6 mg in combination protocols.
  • Survodutide Weekly Research Dosing Protocol

    Moved survodutide researching
    1
    1 Votes
    1 Posts
    106 Views
    RandyR
    For research use only. Not medical advice. Overview Survodutide is a dual GLP-1/glucagon receptor agonist typically researched in the 0.6–6 mg weekly range, with gradual escalation over 10–12 weeks. It produces strong appetite suppression and a pronounced metabolic effect due to its glucagon activity — much more aggressive than standard GLP-1 compounds. Slow titration is essential for GI tolerability. Weekly Titration Schedule Weeks 1–2: Intro Phase Dose: 0.6 mg once weekly Purpose: Allow subjects to adapt to GLP-1 + GC stimulation. Notes: Even this low dose can feel strong for GLP-1-naive subjects. Weeks 3–4: Light Phase Dose: 1.2 mg once weekly Appetite suppression increases significantly here. Hold longer at 0.6 mg if nausea or fullness is excessive. Weeks 5–6: Moderate Phase Dose: 1.8 mg once weekly Represents a comfortable mid-range dose for many subjects. Escalate only if prior doses were well tolerated. Weeks 7–8: Strong Phase Dose: 2.4 mg once weekly This dose often produces robust metabolic effects without overwhelming tolerability. Many researchers remain here for multiple weeks before proceeding. Weeks 9–10: High Phase Dose: 3.6 mg once weekly Strong GC-driven thermogenic activity emerges. If subjects struggle at this point, step back to 2.4 mg until stable. Weeks 11–12: Upper-Tier Phase Dose: 4.8 mg once weekly This was near the top end of phase 2 obesity trial dosing. GI and appetite suppression effects intensify; titrate cautiously. Week 13+ Maintenance Two research-validated maintenance ranges: Standard Maintenance 4.8 mg once weekly Provides excellent efficacy with manageable tolerability. Maximum Maintenance 6.0 mg once weekly Represents the high end used in some modeling and extended research runs. Move to 6.0 mg only after 4.8 mg is fully tolerated for several weeks. Frequency & Timing Once weekly at a consistent time. Due to the glucagon component, many subjects experience delayed nausea (Day 2–3). Avoid rushing escalations — Survodutide hits harder per mg than typical GLP-1s. Cycle Length Titration requires 10–12 weeks minimum. Full research cycles typically last 20–48 weeks depending on goals and maintenance dose. Common Research Notes Survodutide is significantly stronger milligram-for-milligram than semaglutide or tirzepatide due to dual receptor activation. GI load increases steeply with each escalation — slow progression improves tolerability. When used in stacks (e.g., tirz + survo “Ghetto Reta”), researchers often cap survo at 0.6–1.5 mg because synergy multiplies the effect.
  • 0 Votes
    2 Posts
    59 Views
    P
    test
  • 0 Votes
    2 Posts
    151 Views
    P
    Discussion thread for the blog post on PeptideCritic.com. Read the article: HYB’s 10mg “Retatrutide” Disaster: When Your Telegram Plug Sells You a Mystery Peptide Share your thoughts, ask questions, or continue the conversation below!
  • 0 Votes
    1 Posts
    67 Views
    P
    Discussion thread for the blog post on PeptideCritic.com. Read the article: The Rise of Grey Market Peptides: Popularity, Transparency, and Safe Research Practices Share your thoughts, ask questions, or continue the conversation below!
  • 0 Votes
    1 Posts
    69 Views
    P
    Discussion thread for the blog post on PeptideCritic.com. Read the article: Introducing the Finest 3D-Printed Vial Carrying Cases Share your thoughts, ask questions, or continue the conversation below!
  • This topic is deleted!

    Moved
    1
    0 Votes
    1 Posts
    3 Views
  • This topic is deleted!

    Moved
    1
    0 Votes
    1 Posts
    4 Views