If your wife is over the age of 40, I would also look into HRT for her. This would be very effective at restoring quality of sleep for her and would do it more holistically, and work in a synergistic way with peptides.
You can also look into peptides for restoring her GH levels, which also has a major influence on sleep quality.
It's very likely that part of her sleep issues are rooted in hormone loss, be it progesterone, estrogen, testosterone and growth hormone.