I wonder if this applies to Survo also. I've been running survo on my rat for 3 months with the tirz and I'm still getting gout like symptoms in my big toes. Not quite like a gout flare up because it doesn't get all red, but pain to where I can barely walk sometimes. Uric acid levels are in the normal range also. Until recently it was just my left big toe, but a few weeks ago I got it in my right big toe. And then both toes at the same time. Coincidence or causation, I am cycled off cartalax and ara.