@charletonsmith
I'm talking with more and more Tirz and Reta researchers who stall out and have no other alternatives other than to increase the dose fairly substantially, or try a myriad of other supps, etc to break through.
Our bodies are made to adjust to such peptides, co-factors, etc. and if all 4 pathways get opened (if Cagri is added) and "burned", it's hard to tell how long one has to wait until they can be used again, if ever, with the same efficiency.
IF I had it to start all over again, I would have started with Semi instead of Tirz. Although not as much weight loss, you have 3 other pathways to use once the stall comes AND the majority of people who've reached goal weight that I've spoken with and held it there were Semi researchers, now completely off, or are microdosing with good success. I just know of too many people on Tirz and/or Reta who're stalling, as I am at this point and want to preserve some exit routes.
The GIP seems to be really active; not that others are not and I can't prove what I'm thinking but after 6 mo. Tirz (added Survo about 3 mos ago), I'm backing off the Tirz and adding Cagri in hopes of saving the GIP. Cagri is GLP-1 + amylin pathway. Since I'm taking Survo, that's GLP-1 + glucagon pathway; keeping in mind that GLP-1 seems to be much easier to back off of than GIP (anecdotal). Saving the Tirz in freezer for much later, hoping I never need it again.
Keep in mind, this is my own research and not suggesting anyone else do it, or that it works but it just appears, even chemically (organic), the GIP is the key to a big lock. My experiment. I hope what I've said above makes sense.